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Expert Opin Investig Drugs. 2009 Nov;18(11):1715-26. doi: 10.1517/13543780903286388.

Lurasidone: a new drug in development for schizophrenia.

Author information

  • 1Department of Psychiatry, University of California, San Diego, CA 92161, USA. jmmeyer@ucsd.edu

Abstract

BACKGROUND:

Lurasidone is a novel psychotropic agent in development for the treatment of schizophrenia and bipolar disorder.

OBJECTIVES:

This paper describes the development of lurasidone, including its receptor binding affinities, pharmacokinetics, CNS activity in rodent models and results of early clinical efficacy and safety studies in humans.

METHODS:

The available literature on lurasidone was reviewed, including abstracts from medical congresses supplemented by data on file with the sponsor.

RESULTS/CONCLUSIONS:

Lurasidone has a high affinity for dopamine D(2) and serotonin 5-HT(2A) receptors as well as for receptors implicated in enhancement of cognitive function (e.g., 5-HT(7,) 5-HT(1A), alpha(2c)). Lurasidone has no affinity for muscarinic M(1) and histamine H(1) receptors and minimal affinity for alpha(1) adrenoceptors, dopamine D(1) and D(3) receptors, serotonin 5-HT(2C) receptors and alpha(2A) adrenoceptors. Phase II efficacy data indicate that lurasidone doses from 40 to 120 mg/day are effective in the treatment of schizophrenia, with positive symptom reduction exceeding that for negative symptoms, as seen with other antipsychotics. Preclinical data indicate that lurasidone reverses MK-801 induced learning and memory impairment in rodents, and active comparator data from a Phase Ib study of lurasidone 120 mg/day versus ziprasidone 160 mg/day also found a signal for effects on cognition. Phase II studies suggest that lurasidone has no significant QTc prolongation and a benign metabolic profile.

PMID:
19780705
[PubMed - indexed for MEDLINE]
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