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Malawi Med J. 2009 Mar;21(1):12-8.

Impact of iron supplementation on schistosomiasis control in Zambian school children in a highly endemic area.

Author information

  • 1Tropical Diseases Research Centre, P.O. Box 71769, Ndola, Zambia. MwanakasaleV@tdrc.org.zm

Abstract

AIM:

To study impact of once weekly iron supplementation on praziquantel cure rate, Schistosoma haematobium reinfection, and haematological parameters in pupils aged between 9 and 15 years of age in Nchelenge district, Zambia.

METHODS:

Pupils in the intervention group received once weekly dose of ferrous sulphate at 200 mg while those in the control received once weekly vitamin C at 100 mg for up to 9 months. Both study groups received a single dose of praziquantel at baseline.

RESULTS:

S haematobium reinfection intensity was significantly lower in boys in the intervention group than in boys in the control group at 6 months (P < 0.001) and 9 months (P < 0.001) of supplementation. Significantly lower S haematobium reinfection intensity was found in girls in the intervention group than in girls in the control group only at 6 months of supplementation (P = 0.018). Boys in the intervention group were 42% (Adjusted Risk Ratio = 0.58, 95% confidence interval 0.39, 0.86) less likely to be reinfected with S haematobium than in the control group at 6 months follow up.

CONCLUSION:

Once weekly iron supplementation can decrease S haematobium reinfection after 6 months and should be incorporated into school based schistosomiasis control programs in highly endemic areas.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00276224.

PMID:
19780472
PMCID:
PMC3345721
[PubMed - indexed for MEDLINE]
Free PMC Article
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