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Neuron. 2009 Sep 24;63(6):719-21. doi: 10.1016/j.neuron.2009.09.008.

Resting our cortices by going DOWN to sleep.

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  • 1Stanford University Center for Narcolepsy, Palo Alto, CA 94304-5742, USA.


In this issue of Neuron, Vyazovskiy et al. reports on progressive changes in cortical unit activity within extended wakefulness and within extended sleep paralleling changes in EEG slow-wave sleep activity. Sleep debt may be integrated at the level of individual cortical neurons, providing support for the synaptic homeostasis theory.

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