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    World J Gastroenterol. 2009 Sep 28;15(36):4566-70.

    Lack of correlation between p53 codon 72 polymorphism and anal cancer risk.

    Contu SS, Agnes G, Damin AP, Contu PC, Rosito MA, Alexandre CO, Damin DC.

    Department of Surgery, Division of Coloproctology, Clinicas Hospital of Porto Alegre and Federal University of Rio Grande do Sul, 90.035-930 Porto Alegre, Brazil.

    AIM: To investigate the potential role of p53 codon 72 polymorphism as a risk factor for development of anal cancer. METHODS: Thirty-two patients with invasive anal carcinoma and 103 healthy blood donors were included in the study. p53 codon 72 polymorphism was analyzed in blood samples through polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing. RESULTS: The relative frequency of each allele was 0.60 for Arg and 0.40 for Pro in patients with anal cancer, and 0.61 for Arg and 0.39 for Pro in normal controls. No significant differences in distribution of the codon 72 genotypes between patients and controls were found. CONCLUSION: These results do not support a role for the p53 codon 72 polymorphism in anal carcinogenesis.

    PMID: 19777616 [PubMed - indexed for MEDLINE]

    PMCID: PMC2752002

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