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Br J Ophthalmol. 2010 May;94(5):532-5. doi: 10.1136/bjo.2009.160820. Epub 2009 Sep 23.

Topical chemotherapy for ocular surface squamous neoplasia: current status.

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  • 1Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.


Although there are no randomised trials directly comparing topical chemotherapeutic agents mitomycin-C, 5-fluorouracil, and interferon-alpha2b, published studies indicate equal efficacy of these agents for treatment of non-invasive ocular surface squamous neoplasia (80%-88%). 5-Fluorouracil may be preferred, given low incidence of serious side effects and low cost to the patient.

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