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    Bioorg Med Chem Lett. 2009 Nov 1;19(21):6200-4. Epub 2009 Sep 3.

    A naturally occurring brominated furanone covalently modifies and inactivates LuxS.

    Zang T, Lee BW, Cannon LM, Ritter KA, Dai S, Ren D, Wood TK, Zhou ZS.

    Source

    The Barnett Institute and the Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.

    Abstract

    Halogenated furanones, a group of natural products initially isolated from marine red algae, are known to inhibit bacterial biofilm formation, swarming, and quorum sensing. However, their molecular targets and the precise mode of action remain elusive. Herein, we show that a naturally occurring brominated furanone covalently modifies and inactivates LuxS (S-ribosylhomocysteine lyase, EC 4.4.1.21), the enzyme which produces autoinducer-2 (AI-2).

    PMID:
    19775890
    [PubMed - indexed for MEDLINE]
    PMCID: PMC2760616
    Free PMC Article

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