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Curr Opin Cell Biol. 2009 Dec;21(6):816-24. doi: 10.1016/ Epub 2009 Sep 21.

Control of cell growth by the SCF and APC/C ubiquitin ligases.

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  • 1Department of Pathology, NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA.


The ubiquitin-proteasome system plays key roles in the control of cell growth. The cell cycle, in particular, is highly regulated by the functions of the SCF and APC/C ubiquitin ligases, and perturbation of their function can result in tumorigenesis. Although the SCF and APC/C complexes are well established in growth control pathways, many aspects of their function remain unknown. Recent studies have shed light on the mechanism of SCF-mediated ubiquitination and new functions for the SCF complex and APC/C. Our expanding understanding of the roles of the SCF and APC/C complexes highlight the potential for targeted molecular therapies.

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