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Nature. 1990 Oct 11;347(6293):528-33.

Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.

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  • 1Department of Chemistry, University of California, San Diego, La Jolla 92093.

Abstract

Mutations at the mouse dwarf locus (dw) interrupt the normal development of the anterior pituitary gland, resulting in the loss of expression of growth hormone, prolactin and thyroid-stimulating hormone, and hypoplasia of their respective cell types. Disruptions in the gene encoding the POU-domain transcription factor, Pit-1, occur in both characterized alleles of the dwarf locus. The data indicate that Pit-1 is necessary for the specification of the phenotype of three cell types in the anterior pituitary, and directly link a transcription factor to commitment and progression events in mammalian organogenesis.

PMID:
1977085
[PubMed - indexed for MEDLINE]
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