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    Lancet. 1990 Oct 20;336(8721):963-4.

    Evoked potentials in assessment and follow-up of patients with Wilson's disease.

    Grimm G, Oder W, Prayer L, Ferenci P, Madl C.

    Source

    Department of Medicine, University of Vienna, Austria.

    Abstract

    Treatment of 9 patients with Wilson's disease was prospectively studied with evoked potentials and magnetic resonance imaging (MRI). Oral penicillamine therapy led to a decrease in auditory brainstem (ABP) and somatosensory (SEP) conduction times in 6 and 4 neurologically symptomatic patients, respectively. ABP and SEP were normal in 3 other symptom-free patients. MRI showed cerebral lesions in 4 of 7 patients. Quantified indices of brain atrophy were unaffected by treatment. ABP and SEP may reveal a reversible component of the disease that cannot be detected by MRI, and may be a more sensitive measure of treatment efficacy.

    PMID:
    1977004
    [PubMed - indexed for MEDLINE]

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