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J Biol. 2009 Sep 21;8(8):70. doi: 10.1186/jbiol177.

The 'stem cell' concept: is it holding us back?

Author information

  • Center for Complex Biological Systems, Department of Developmental and Cell Biology, and Department of Biomedical Engineering, University of California at Irvine, Irvine, CA 92697-2300, USA. adlander@uci.edu

Abstract

Developmental biology, regenerative medicine and cancer biology are increasingly occupied with the molecular characterization of stem cells. Yet recent work adds to a growing body of literature suggesting that 'stemness' cannot be reduced to the molecular features of cell types, and is instead an emergent property of cell lineages under feedback control.

PMID:
19769787
[PubMed - indexed for MEDLINE]
PMCID:
PMC2776917
Free PMC Article
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