Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Top Microbiol Immunol. 2009;333:109-32. doi: 10.1007/978-3-540-92165-3_5.

Live attenuated vaccines for pandemic influenza.

Author information

  • 1Laboratory of Infectious Diseases, NIAID, NIH, Building 33, 3E 13C.2, 33 North Drive, MSC 3203, Bethesda, MD 20892-3203, USA.

Abstract

In this chapter, we will review the development of and clinical experience with the currently licensed seasonal live attenuated influenza vaccines (LAIV) and preclinical studies of H5, H7, and H9 live attenuated pandemic influenza vaccine candidates. Vectored vaccine approaches will not be reviewed in this chapter. Experience with seasonal influenza vaccination has demonstrated the safety and efficacy of LAIV in both children and adults; moreover, cross-protection among antigenically distinct viruses within the same subtype may be induced by LAIV. While clinical studies and further characterization of the immunologic response to avian influenza viruses are still needed, the experience with seasonal LAIV underscores the potential of live attenuated vaccines to play an important role in the event of a pandemic.

PMID:
19768402
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Write to the Help Desk