J Virol. 1990 Nov;64(11):5605-10.

Two receptors are required for antibody-dependent enhancement of human immunodeficiency virus type 1 infection: CD4 and Fc gamma R.

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Department of Medicine, University of Massachusetts Medical School, Worcester 01655.

Abstract

Evidence of antibody-dependent enhancement of human immunodeficiency virus type 1 (HIV-1) infection via Fc receptor (FcR) was published previously (A. Takeda, C. U. Tuazon, and F. A. Ennis, Science 242:580-583, 1988). To define the entry mechanism of HIV-1 complexed with anti-HIV-1 antibody, we attempted to determine the receptor molecules responsible for mediating enhancement of HIV-1 infection of monocytic cells. Monoclonal antibodies to FcRI for immunoglobulin G substantially blocked antibody-dependent enhancement of HIV-1 infection. Furthermore, we demonstrate a requirement for the CD4 molecule in antibody-enhanced HIV-1 infection via FcR. Soluble CD4 prevented infection by HIV-1 antibody-treated virus, and enhancement of infection of virus-antibody complexes was abrogated by a monoclonal antibody to CD4 (anti-Leu3a antibody). Treatment of human macrophages with an anti-CD4 antibody also inhibited antibody-enhanced HIV-1 infection of macrophages, supporting our contention that antibody-dependent enhancement of HIV-1 infection via FcR requires CD4 interaction with the virus glycoprotein.

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Fc receptors for IgG (Fc gamma Rs) on human monocytes and macrophages are not infectivity receptors for human immunodeficiency virus type 1 (HIV-1): studies using bispecific antibodies to target HIV-1 to various myeloid cell surface molecules, including the Fc gamma R. [Proc Natl Acad Sci U S A. 1991]
Fc receptors for IgG (Fc gamma Rs) on human monocytes and macrophages are not infectivity receptors for human immunodeficiency virus type 1 (HIV-1): studies using bispecific antibodies to target HIV-1 to various myeloid cell surface molecules, including the Fc gamma R.
Connor RI, Dinces NB, Howell AL, Romet-Lemonne JL, Pasquali JL, Fanger MW. Proc Natl Acad Sci U S A. 1991 Nov 1; 88(21):9593-7.
Antibody-enhanced infection by HIV-1 via Fc receptor-mediated entry. [Science. 1988]
Antibody-enhanced infection by HIV-1 via Fc receptor-mediated entry.
Takeda A, Tuazon CU, Ennis FA. Science. 1988 Oct 28; 242(4878):580-3.
The Fc and not CD4 receptor mediates antibody enhancement of HIV infection in human cells. [Science. 1989]
The Fc and not CD4 receptor mediates antibody enhancement of HIV infection in human cells.
Homsy J, Meyer M, Tateno M, Clarkson S, Levy JA. Science. 1989 Jun 16; 244(4910):1357-60.
Review FcR-mediated enhancement of HIV-1 infection by antibody. [AIDS Res Hum Retroviruses. 1990]
Review FcR-mediated enhancement of HIV-1 infection by antibody.
Takeda A, Ennis FA. AIDS Res Hum Retroviruses. 1990 Aug; 6(8):999-1004.
Review Enhancing antibodies in HIV infection. [Parasitology. 1997]
Review Enhancing antibodies in HIV infection.
Füst G. Parasitology. 1997; 115 Suppl:S127-40.

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Two receptors are required for antibody-dependent enhancement of human immunodeficiency virus type 1 infection: CD4 and Fc gamma R.

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