Format

Send to

Choose Destination
See comment in PubMed Commons below

Molecular pathogenesis of liver fibrosis.

Author information

  • 11318 Biomedical Sciences Building, UC San Diego Health Sciences, 9500 Gilman Drive, La Jolla, CA 92093-0602, USA. dbrenner@ucsd.edu

Abstract

Hepatic fibrosis is the final common pathway for most chronic liver diseases. The cell responsible for hepatic fibrosis appears to be the activated myofibroblast. The myofibroblast may be derived from quiescent hepatic stellate cells, epithelial to mesenhymal transition, or derived from bone marrow precursors. Studies in primary cultures of myofibroblasts and in mouse models of hepatic fibrosis have revealed several common pathophysiological mechanisms. Hepatic fibrosis is strongly associated with oxidative stress, increased transforming growth factor beta, hepatocyte death, and chronic inflammation. Finally, the reversal of fibrosis depends upon the elimination of the activated myofibroblast.

PMID:
19768189
PMCID:
PMC2744540
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk