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Nat Genet. 2009 Oct;41(10):1116-21. doi: 10.1038/ng.450. Epub 2009 Sep 20.

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.

Collaborators (622)

Bollina P, Bonnington S, Cooper D, Doble A, Doherty A, Durkan G, Elliott E, Gillatt D, Herbert P, Holding P, Howson J, Jones M, Kockelbergh R, Kynaston H, Lennon T, Lyons N, Leung H, Moody H, Powell P, Prescott S, Thompson P, Durkan G, Edwards NS, Fisher C, Jameson C, Barrett S, Kelham P, Brown PM, George A, Marsden G, Davis M, Wallace DM, Doherty A, Bhatt RI, Subramonian K, Arrand J, Flanagan L, Bradley SA, Pedersen J, Smith C, Bagnato M, Nelson C, O'Mara T, Hinze K, VandenBergh P, Newman B, Nicol D, Yaxley J, Ferguson M, Nicol D, Stankovich J, Thomson R, FitzGerald L, Foote S, Challis D, McArdle J, McKay J, Banks A, McWhirter R, Butorac K, Smark H, Blizzard L, Popov E, Kachakova D, Dodova R, Belcheva O, Nikolov M, Mitev V, Vlahova A, Dikov T, Christova S, Hamel N, Kotar K, Hou JG, Xu DF, Chang WJ, Xu XX, Stenman UH, Mattila H, Siltanen S, Pakkanen S, Isotalo J, Matikainen M, Surowy H, Brugger M, Wiest I, Weber B, Herkommer K, Paiss T, Kuefer R, Dubrowinskaja N, von Klot C, Kuczyk M, Hillemanns P, Bremer M, Karstens JH, Machtens S, Biedermann C, Peter HU, Defabiani N, Bieri S, Girardet C, Konzelmann I, Stalder M, Meier MM, Wang L, Cunningham J, Zuhlke KA, Johnson EK, Montie JE, Zakariah B, Park HY, Radein S, Rincon M, Zachariah B, Zeigler-Johnson C, Spangler E, Coomes M, Gallagher S, Walker A, Cohen NP, Conn I, Swami KS, Moffat LE, Kenwrick S, Patterson H, Waite K, Doble A, Wiles V, Irwin C, Lancashire M, Ellis BW, Kulkarni R, Gurun RM, Hollins GW, Mahmood R, Meddings RN, Briggs T, Chong I, Gelister JS, Mumtaz F, Ravi R, Malone PR, Pengelly A, Dodds D, Featherston C, Hendry D, Jones G, Kirk D, Russell JM, Siva M, Leader M, Thomas RJ, Morrison P, O'Sullivan J, Shum L, Stewart D, Feggetter J, O'Brien J, Cole T, Cruger D, Maher ER, Neilson D, Wemyss-Holden GD, Susnerwala S, Bahl A, Persad R, Wright M, Zang A, Leone P, Tahir S, Parikh O, Virdi J, Izegbu V, Bellringer J, Christmas TJ, Falconer A, Carter S, Hrouda D, Karp SJ, Bower M, Dinneen M, Brock C, Gilbert H, Jenkins P, Boucher NR, James MJ, Cowan R, Evans DG, Livsey J, Logue J, Wylie JP, Lalloo F, Sugden E, Brewster SF, Cole DJ, Connell C, Protheroe A, Saxby MF, Ryan PG, Peake D, Coe M, Errington RD, Ibrahim A, Syndikus I, Booth CM, Corr J, Lynch M, Callaghan PS, Plail R, Ash D, Coyle C, Bottomley D, Powell C, Chilton C, Henley M, Peracha AM, Williams JH, Williams S, Muthukumar D, Thomas SA, Dickinson AJ, Hammonds J, McInerney P, Pascoe S, Sells H, Tyrell CJ, Tindall SF, Afzal N, Andrews S, Cornaby AJ, Archbold JA, Kunkler IH, Folkes A, Money-Kyrle J, Bax NA, Lawrence WT, McKinna F, Rimington PR, Dawson C, Khan F, Charig C, Le Roux P, Hehir M, Smith MF, Tweedle J, Glenister J, Eden CD, Langley SE, Montgomery B, Naerger H, Palfrey E, Wilson R, Qureshi KN, Apakama I, Prasad K, Al-Samerraie, Emmerson L, Nethersell A, Srinivasan, Glaholm J, Ohja H, Dahar N, Daruwala P, Beck R, Iacovou JW, Harper P, Perry M, Popert R, Cahill D, Dobbs HJ, Izatt L, O'Brien TS, Tong, Kelkar AR, Waxman JH, Badenoch D, O'Donoghue N, Singh P, Lawson A, Pancharatnam M, Shah N, Sole GM, Pope AJ, Clarke NW, Ferro M, Harney JM, Douglas SF, Banerjee G, Donaldson P, Scrase C, Chadwick D, Hardman PD, Hindmarsh JR, Suresh G, Mithal N, Murray KW, Davison OW, Baxter-Smith D, Motiwala H, Barber N, Muir G, Copland RF, Dick J, Morley R, Thompson A, Van As N, Butterworth PC, Griffiths TR, Kockelbergh R, Osborn D, Terry T, Barwell J, Trembath RC, Javle P, Basu P, Mark I, Panades M, Sreenivasan T, Hanbury DC, McNicholas TA, Davidson S, Holden D, Namasivayam S, Reddy PJ, Beesley S, Ford TF, Lewis J, Chetiyawardana AD, Smith J, Mufti G, Andrews H, Walker EM, Anjum I, Bose P, Lucas MG, Ashford RF, Dickson J, Hoskin P, Hughes R, Ostler P, Churn MJ, Cooke P, Inglis JA, Philp NH, Waymont B, Leung H, McMenemin R, Pedley I, Roberts JT, Lee JO, Ho ET, Irving S, Mills R, Sethia KK, Webb RJ, Sheehan DJ, Barnes DG, Chow WM, Costello CB, Elwell C, Elkabir J, Fermont D, Mee AD, Bishop M, Cole O, Harriss DR, Lemburger RJ, Sokal M, Sundar S, Dunn M, Urwin GH, Benson R, Baria, Memon, Biyani CS, Browning TJ, Murphy M, Sundaram SK, Weston PM, Goode TD, Hickish T, Castle BM, Cummings, Eccles D, Harvey-Hills N, Mort D, Menzes P, Ahmed M, Dawkins G, Bhatt RI, Doherty A, El-Modir A, Hughes M, Luscombe CJ, Wallace DM, James N, Subramonian K, Hampson SJ, Gibbs S, Chakraborti P, Kumar M, Whillis D, Kourah M, Parys BT, Lau MW, Brown R, Fawcett D, Rogers PB, Lee L, Mobb GE, Pantelides ML, Bramble FJ, Brock S, Carter CJ, Davies J, McBride D, Rundle J, Wedderburn A, Collinson M, Cox R, Ellis R, Newton R, O'Rourke JS, Thomson AH, Wheatley D, Stott MA, Pocock RD, Rankin J, Crundwell M, Kaisary A, Pigott K, Bates CA, Beese G, Bowsher WG, Carter AC, Gower RL, Hamdy FC, Anderson J, Harrison GS, Adamson A, Duffy P, Rowbotham C, Woolfenden KA, Cornford PA, Bancroft E, Dearnaley D, Huddart R, Jhavar S, Khoo V, Locke I, Mitra A, Parker C, Shanley S, Woodhouse C, Wynne C, Horwich A, Ogden C, Fisher C, Jameson C, Sharma NK, Birtle A, Mokete, Ragavan N, Read, Watson ME, Wise M, Blades R, Matenhelia S, Beacock C, Elves AW, Srihari NN, Birch B, Heath CM, Laing R, Bloomfield DJ, Coker C, Deutsch GP, Fletcher M, Larner TR, Murrell S, Nawrocki, Robinson A, Wilkins M, Frim O, Gallegos C, Howell GP, McFarlane J, Newman H, Samanci A, Campbell A, Guy PJ, McIntosh G, Hamilton C, Hawkyard S, Robertson A, Coombs L, Dixit S, Morris SB, Ball AJ, Carr TW, Koreich O, Lodge R, Prejbisz JW, Robinson AC, Abrams PH, Corolis, Drake, Gillatt D, Graham J, Rowe, Keeley FX, McGrath, Schwaibold H, Vesey S, Thurston A, Watkin NA, Chinegwundoh FI, Lee A, Mair GH, Nargund V, Oliver T, Plowman PN, Anson K, Hodgson S, Saggar AK, Bailey MJ, Gordon EM, Taylor JW, Boyd PJ, Jones CR, Walker R, Joss S, Whelan P, Aparcia F, Hudson L, Prescott S, Patel A, Holmes SA, Dunsmuir WD, Beaney RP, Calman F, Glass JM, Simcock R, James RL, Rao Y, Scoble JE, Adeyoju A, Brown S, Collins G, Oakley N, O'Reilly P, Lloyd P, Lloyd S, Alcock C, Greenland J, Green D, Brough R, O'Boyle PJ, Macdonagh RP, Speakman MJ, Violet J, Mostafid AH, Kirby RS, Kirollos MM, Lydon A, MacDermott JP, Mason R, Carnell DM, Emberton M, Harland SJ, O'Donoghue E, Payne H, Duchesne GM, Blacklock AR, Desai KM, Grieve R, Humber C, Sriram R, Stockdale A, Willis M, Worlding J, Bailey K, Murray A, Datta S, Hughes O, Kynaston H, Matthews PN, Barber J, Lester J, Mason MD, Rowley K, Tilsley W, Longmuir M, Robinson LQ, Jones DA, Lewis DC, Strachan JR, Crisp JC, Mitchell S, Sherwin E, McLaren D, Taylor JW, Tulloch DN, Ferguson C, Kirkbride P, Brown R, Karim O, Laniado M, Philp T, Wells P, Beard R, Liston T, Woodhams S, De Bolla AR, Kelleher JP, Weaver A, Parker CH, Porter T, Stower MJ, Wilson JR, Ahiaku EK.

Author information

  • 1The Institute of Cancer Research, Sutton, Surrey, UK.

Abstract

Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33)).

PMID:
19767753
[PubMed - indexed for MEDLINE]
PMCID:
PMC2846760
Free PMC Article

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