Physiol Meas. 2009 Oct;30(10):L9-L11; author reply L13-L14. Epub 2009 Sep 18.

Comment on 'Estimating a modified Grubb's exponent in healthy human brains with near infrared spectroscopy and transcranial Doppler'.

Abstract

The relationship between cerebral blood volume (CBV) and blood flow (CBF) has gained widespread interest because of its utility in using functional magnetic resonance imaging and optical imaging methods to estimate the cerebral metabolic rate of oxygen (CMRO(2)). A recent paper by Leung et al (2009 Physiol. Meas. 30 1-12) nicely presents measurements relating CBV to cerebral blood flow velocity (CBFV) as measured by near infrared spectroscopy and transcranial Doppler, respectively. They suggest that this relationship cannot be inverted to estimate CBF (or CBFV) from CBV, and that doing so to estimate CMRO(2) is inappropriate. We argue that these data, and other related published data, do permit the estimation of CBF from CBV and thus enable CMRO(2) to be estimated when only measures of CBV and deoxygenated hemoglobin are available.

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Physiol Meas. 2009 Jan;30(1):1-12.

PMID:: 19767672; [PubMed - indexed for MEDLINE]

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Estimating a modified Grubb's exponent in healthy human brains with near infrared spectroscopy and transcranial Doppler. [Physiol Meas. 2009]
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Leung TS, Tachtsidis I, Tisdall MM, Pritchard C, Smith M, Elwell CE. Physiol Meas. 2009 Jan; 30(1):1-12. Epub 2008 Nov 27.
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