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Res Microbiol. 2009 Nov;160(9):667-76. doi: 10.1016/j.resmic.2009.08.014. Epub 2009 Sep 16.

Proteolysis of sigmaS (RpoS) and the general stress response in Escherichia coli.

Author information

  • Institut für Biologie, Mikrobiologie, Freie Universität Berlin, Königin-Luise-Str. 12-16, 14195 Berlin, Germany. rhenggea@zedat.fu-berlin.de

Abstract

The sigma(S) (RpoS) subunit of RNA polymerase is the master regulator of the general stress response in Escherichia coli. Regulation of sigma(S) occurs at the levels of transcription, translation, proteolysis and protein activity. As sigma(S) has become a paradigm for regulated proteolysis in bacteria, this review summarizes our current knowledge about the molecular mechanisms and multiple signal integration in sigma(S) degradation.

PMID:
19765651
[PubMed - indexed for MEDLINE]
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