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Nat Rev Immunol. 2009 Oct;9(10):679-91. doi: 10.1038/nri2622. Epub 2009 Sep 18.

Skin immune sentinels in health and disease.

Author information

  • 1St. John's Institute of Dermatology, King's College London, UK. frank.nestle@kcl.ac.uk

Abstract

Human skin and its immune cells provide essential protection of the human body from injury and infection. Recent studies reinforce the importance of keratinocytes as sensors of danger through alert systems such as the inflammasome. In addition, newly identified CD103(+) dendritic cells are strategically positioned for cross-presentation of skin-tropic pathogens and accumulating data highlight a key role of tissue-resident rather than circulating T cells in skin homeostasis and pathology. This Review focuses on recent progress in dissecting the functional role of skin immune cells in skin disease.

PMID:
19763149
[PubMed - indexed for MEDLINE]
PMCID:
PMC2947825
Free PMC Article

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