Clin Pharmacol Ther. 2009 Oct;86(4):360-2.

Predicting age-specific dosing of antipsychotics.

Source

Centre for Addiction and Mental Health, Geriatric Mental Health Program, Ontario, Canada.

Abstract

Antipsychotic medications are the standard of care for both acute and maintenance treatment of schizophrenia, the latter requiring an indefinite treatment across a patient's life span. However, dosing and tolerability of antipsychotics have been studied primarily in younger patients, and very limited data are available for age- and phase-specific dosing. This leaves the clinician with no guidance on dose adjustment as patients grow older-an issue of critical importance, especially in light of recent concerns about increased morbidity and mortality associated with antipsychotics.

PMID:: 19763115; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Molecular Biology Databases

Pharmacogenomic Annotation 827856458 for PMID:19763115 [PharmGKB] - Pharmacogenomics Knowledge Base

Supplemental Content

Save items

Related citations in PubMed

Review Sensitivity to antipsychotic drugs in older adults. [Curr Psychiatry Rep. 2010]
Review Sensitivity to antipsychotic drugs in older adults.
Leon C, Gerretsen P, Uchida H, Suzuki T, Rajji T, Mamo DC. Curr Psychiatry Rep. 2010 Feb; 12(1):28-33.
Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms. [Am J Geriatr Psychiatry. 2009]
Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms.
Uchida H, Kapur S, Mulsant BH, Graff-Guerrero A, Pollock BG, Mamo DC. Am J Geriatr Psychiatry. 2009 Mar; 17(3):255-63.
Review Dosing of antipsychotics in schizophrenia across the life-spectrum. [Prog Neuropsychopharmacol Biol...]
Review Dosing of antipsychotics in schizophrenia across the life-spectrum.
Uchida H, Mamo DC. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Aug 31; 33(6):917-20. Epub 2009 May 6.
Review [Theory in antipsychotic drug therapy for schizophrenia]. [Seishin Shinkeigaku Zasshi. 2006]
Review [Theory in antipsychotic drug therapy for schizophrenia].
Tomioka S, Ishigooka J. Seishin Shinkeigaku Zasshi. 2006; 108(6):614-8.
Need for a new framework to understand the mechanism of all antipsychotics. [J Clin Psychiatry. 2000]
Need for a new framework to understand the mechanism of all antipsychotics.
Stip E, Liddle PF, Soucy JP. J Clin Psychiatry. 2000 May; 61(5):387-8.

See reviews... See all...

Cited by 1 PubMed Central article

Geriatric mental health: Recent trends in molecular neuroscience. [Indian J Psychiatry. 2010]
Geriatric mental health: Recent trends in molecular neuroscience.
Sathyanarayana Rao TS, Praveena B, Jagannatha Rao KS. Indian J Psychiatry. 2010 Jan; 52(1):3-5.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Predicting age-specific dosing of antipsychotics.
Predicting age-specific dosing of antipsychotics.
Clin Pharmacol Ther. 2009 Oct ;86(4):360-2.

PubMed
ECT and tardive dyskinesia.
ECT and tardive dyskinesia.
J Geriatr Psychiatry Neurol. 1990 Apr-Jun ;3(2):106-9.

PubMed
NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipa...
NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain.
EMBO J. 2009 Oct 7 ;28(19):2885-95. Epub 2009 Sep 17 .

PubMed
The three main monotheistic religions and gm food technology: an overview of per...
The three main monotheistic religions and gm food technology: an overview of perspectives.
BMC Int Health Hum Rights. 2009 Aug 22 ;9:18.

PubMed
Properties of untranslated regions of the S. cerevisiae genome.
Properties of untranslated regions of the S. cerevisiae genome.
BMC Genomics. 2009 Aug 22 ;10:391.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: