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Expert Opin Pharmacother. 2009 Oct;10(15):2555-62. doi: 10.1517/14656560903277228.

Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris.

Author information

  • 1Department of Dermatology, Wake Forest University School of Medicine, Center for Dermatology Research, Winston-Salem, NC 27157-1071, USA.

Abstract

BACKGROUND:

Owing to the use of topical and systemic antibiotics for acne vulgaris, the incidence of antibiotic-resistant Propionibacterium acnes is increasing worldwide. Topical benzoyl peroxide (BPO) is an alternative to antibiotics in the treatment of acne vulgaris.

OBJECTIVE:

This review describes and evaluates recent clinical literature regarding the efficacy and tolerability of BPO.

METHODS:

A PubMed literature search was conducted using the keywords benzoyl peroxide, acne, and combination therapy.

RESULTS:

BPO is equally effective at concentrations of 2.5, 5.0 and 10%. However, a concentration-dependent irritant dermatitis can occur with higher concentrations. The efficacy of BPO can be enhanced when used in combination with topical retinoids, antibiotics and tertiary amines. BPO-containing combinations do not induce bacterial resistance and are important first-line treatments for mild to moderate acne vulgaris.

PMID:
19761357
[PubMed - indexed for MEDLINE]
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