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Muscle Nerve. 2009 Oct;40(4):589-94. doi: 10.1002/mus.21389.

Location of myofiber damage in skeletal muscle after lengthening contractions.

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  • 1Department of Physiology, School of Medicine, University of Maryland, 685 West Baltimore Street, Baltimore, Maryland 21201, USA.


High-force lengthening contractions are associated with muscle damage and pain, and the muscle-tendon junction is commonly cited as the primary area where myofiber damage occurs. We induced injury in the rat tibialis anterior muscle and acquired magnetic resonance imaging (MRI) images postinjury. We also assayed membrane damage and quantified the number of centrally nucleated myofibers throughout the injured muscles. Results suggest that myofiber injury occurs primarily in the middle portion of the muscle, with interstitial edema in the middle and distal portions.

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