Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cancer Causes Control. 2009 Nov;20(9):1723-1731. doi: 10.1007/s10552-009-9424-x.

Pancreatitis and pancreatic cancer in two large pooled case-control studies.

Author information

  • 1Department of Epidemiology and Biostatistics, School of Medicine, University of California, 3333 California St. Suite 280, San Francisco, CA 94143, USA. paige.bracci@ucsf.edu

Abstract

OBJECTIVE:

The association between duration of pancreatitis and pancreatic cancer has not been well characterized in large population-based studies. We conducted detailed analyses to determine the association between pancreatitis onset and pancreatic cancer risk.

METHODS:

Data from two case-control studies of pancreatic cancer (n = 4515) in the San Francisco Bay Area and the M.D. Anderson Cancer Center were pooled for analysis (1,663 cases, 2,852 frequency-matched controls). Adjusted odds ratios (OR) were estimated using a random-effects model. Results In the pooled multivariable model, history of pancreatitis was associated with a 7.2-fold increased risk estimate for pancreatic cancer [95% confidence interval (CI): 4.0, 13]. The risk estimate was nearly 10-fold in participants aged <55 years (OR = 9.9, 95% CI: 3.5, 28). A shorter temporal history of pancreatitis was more closely associated with pancreatic cancer than was a longer temporal history: <3 years (OR = 29, 95% CI: 12, 71), 3-10 years (OR = 2.6, 95% CI: 1.5, 5.6), and >10 years (OR = 1.8, 95% CI: 0.7, 4.5, p trend < 0.001).

CONCLUSION:

A short temporal history of pancreatitis was highly associated with pancreatic cancer, suggesting that pancreatitis may be an early manifestation of pancreatic cancer in some individuals. Pancreatic cancer should be considered in the differential diagnosis of individuals with an episode of pancreatitis.

PMID:
19760029
[PubMed - indexed for MEDLINE]
PMCID:
PMC2767517
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer Icon for PubMed Central
    Loading ...
    Write to the Help Desk