Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Hum Lact. 2009 Nov;25(4):451-4. doi: 10.1177/0890334409345496. Epub 2009 Sep 16.

Transfer of metyrapone and its metabolite, rac-metyrapol, into breast milk.

Author information

  • 1Department of Pharmacy, Women's and Children's Hospital, North Adelaide, South Australia.

Abstract

Metyrapone, an inhibitor of corticosteroid biosynthesis, is used in the diagnosis and treatment of adrenocortical hyperfunction. The authors describe the excretion of metyrapone and its metabolite, rac-metyrapol, in milk from a lactating woman requiring metyrapone treatment (250 mg 4 times daily). At steady state, the average concentrations in milk and absolute and relative infant doses were 11 microg/L, 1.7 microg/kg/d, and 0.02%, respectively, for metyrapone, and 48.5 microg/L, 7.3 microg/kg/d, and 0.08%, respectively, for rac-metyrapol. The findings suggest that maternal metyrapone use during breastfeeding is extremely unlikely to be a significant risk for the breastfed infant.

PMID:
19759353
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk