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BMC Med. 2009 Sep 16;7:48. doi: 10.1186/1741-7015-7-48.

Human cellular restriction factors that target HIV-1 replication.

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  • 1Laboratory of Molecular Microbiology, NIAID, the National Institutes of Health, Bethesda, Maryland, USA.

Abstract

Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5alpha), and cellular microRNAs as examples of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions.

PMID:
19758442
[PubMed - indexed for MEDLINE]
PMCID:
PMC2759957
Free PMC Article
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