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Clin Auton Res. 2009 Dec;19(6):343-6. doi: 10.1007/s10286-009-0026-1.

Circulating endocannabinoid concentrations during orthostatic stress.

Author information

  • 1Franz Volhard Clinical Research Center, Helios Klinikum-Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany.

Abstract

BACKGROUND:

In animals, the endocannabinoid system is activated during hemodynamic insults and restrains blood pressure in part through sympathetic inhibition.

MATERIALS AND METHODS:

We tested the hypothesis that hemodynamic stress elicited by head-up tilt testing increases systemic endocannabinoid concentrations in humans and that excessive endocannabinoid availability predisposes to presyncope.

RESULTS:

With head-up tilt, 2-arachidonoylglycerol increased, whereas anandamide remained unchanged.

CONCLUSIONS:

In contrast to our expectations, anandamide plasma concentration at rest was directly correlated with orthostatic tolerance, rather than intolerance.

PMID:
19756829
[PubMed - indexed for MEDLINE]
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