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Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.
Unité de Neurobiologie et Pharmacologie (U. 109) de l'INSERM, Paris, France.
A dopamine receptor has been characterized which differs in its pharmacology and signalling system from the D1 or D2 receptor and represents both an autoreceptor and a postsynaptic receptor. The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions. It seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease, that were previously thought to interact only with D2 receptors.
PMID: 1975644 [PubMed - indexed for MEDLINE]
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Cited by 75 PubMed Central articles
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The four As associated with pathological Parkinson disease gamblers: anxiety, anger, age, and agonists.
Shapiro MA, Chang YL, Munson SK, Jacobson CE, Rodriguez RL, Skidmore FM, Okun MS, Fernandez HH.
Neuropsychiatr Dis Treat. 2007 Feb; 3(1):161-7.
[Neuropsychiatr Dis Treat. 2007]
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POSTER COMMUNICATIONS.
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Br J Pharmacol. 1993 Oct; 110(Suppl):81P-184P.
[Br J Pharmacol. 1993]
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ReviewPharmacotherapy of methamphetamine addiction: an update.
Elkashef A, Vocci F, Hanson G, White J, Wickes W, Tiihonen J.
Subst Abus. 2008; 29(3):31-49.
[Subst Abus. 2008]
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