Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nature. 1990 Sep 13;347(6289):146-51.

Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.

Author information

  • 1Unité de Neurobiologie et Pharmacologie (U. 109) de l'INSERM, Paris, France.

Abstract

A dopamine receptor has been characterized which differs in its pharmacology and signalling system from the D1 or D2 receptor and represents both an autoreceptor and a postsynaptic receptor. The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions. It seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease, that were previously thought to interact only with D2 receptors.

PMID:
1975644
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk