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Am J Dermatopathol. 2010 Feb;32(1):9-14. doi: 10.1097/DAD.0b013e3181a903c4.

Mask-like metastasis: report of 2 cases of 4 eyelid metastases and review of the literature.

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  • 1Servicio de Dermatología, Fundación Instituto Valenciano de Oncología, Valencia, España.


Bilateral periorbital edema and swelling are frequent in clinical practice and are commonly attributed to orbital contact dermatitis due to different drugs and cosmetic products. However, when there is a background of a solid cancer, the possibility of eyelid metastasis should be also considered. Metastases to the eyelids are rare, and in most cases, these lesions are unilateral. Because only a few cases of bilateral involvement have been reported in the literature, clinical and morphological data of this variant are under recognized. We report the clinical and histopathological characteristics of 2 patients with 4 eyelid metastasis and review the previous cases reported in the literature.

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