Biochem Biophys Res Commun. 1990 Aug 31;171(1):216-21.

Molecular evolution and zinc ion binding motif of leukotriene A4 hydrolase.

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Protein Engineering Research Institute, Osaka, Japan.

Abstract

Leukotriene A4 (LTA4) hydrolase belongs to the aminopeptidase N family. In order to investigate the molecular evolution and physiological significance of LTA4 hydrolase, the enzymes belonging to the family were aligned and a phylogenetic tree was constructed. From the alignment, it was found that three residues involved in zinc binding and one residue of the active sites of aminopeptidases N were conserved in LTA4 hydrolase. In agreement with the observation, LTA4 hydrolase is a zinc protein as determined by atomic absorption spectroscopy.

PMID:: 1975494; [PubMed - indexed for MEDLINE]

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Molecular evolution and zinc ion binding motif of leukotriene A4 hydrolase.

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