Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Arch Ophthalmol. 2009 Sep;127(9):1115-28. doi: 10.1001/archophthalmol.2009.233.

A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with standard care to treat vision loss associated with macular Edema secondary to branch retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study report 6.

Collaborators (1292)

Ip MS, Fisher M, Nardi B, Cahill NT, Scott IU, VanVeldhuisen PC, Oden NL, Figueroa MJ, Charlton A, Guan E, Moreno O, Van Dyke J, Bailey T, Robinson C, Frasketi M, Blodi BA, Christianson DJ, Elledge J, Gama V, Glander KE, Goulding A, Myers DJ, Reed SB, Vargo P, Warren KJ, Redford M, Blodi BA, Figueroa MJ, Ip MS, Oden NL, Redford M, Scott IU, VanVeldhuisen PC, Jumper JM, Oestreich N, Connett JC, Blodi BA, Blumenkranz MS, Bressler NM, Csaky K, Davis MD, Gorin M, Haller JA, Ip MS, Johnson MW, Lindblad A, Doft BH, Fekrat S, Figueroa MJ, Finkelstein D, Oden NL, Redford M, Scott IU, VanVeldhuisen PC, Schwartz J, Rial J, Adams J, Farlow B, Lincoln P, Farrell H, Phoebus J, Shah G, Blinder K, Engelbrech N, Thomas M, Joseph D, Holekamp N, Weeks R, Light P, Wehmeier J, Raeber M, Wright T, Nobel V, Boyd L, Walters C, Ressel T, Ray S, Verne A, Leong C, Daniels S, Ting TD, Dowell K, Aguilos M, Moreci C, Hanamoto F, Williams M, Takahara S, Tejada R, Combs W, Teshima-McCormick S, Pieramici D, Nasir M, Avery R, Castellarin A, See R, Couvillion S, Robbins E, Norton T, Davies S, Turner J, Cook S, Basefsky J, Smith R, Tramel L, Guist M, Kruzel M, Boyer K, Sterling A, Avery K, Magana L, Mincey G, Schafer ML, Fleming J, Fulghum L, McVerry W, Pierce SJ, Taylor AK, Coley T, West M, Cole M, Dick J, Gross J, Fishburne B, Magee M, Enlow J, Cummings P, Flowers A, Bequette C, Henry K, Price R, Purvis H, Christoff R, Hoerner S, Hawkins H, Lovit H, Fore C, Gabriel R, Bland K, Lauer A, Hwang T, Wilson D, Stout JT, Flaxel C, Pope S, Martin D, Lundquist A, West K, Rossi J, Pickell S, Gaultney J, Wallace P, Redenbo E, Howell C, Steinkamp P, Rice P, Toomey M, Nolte S, Hanel S, Vahrenwald D, Ira S, Indermill C, Tolentino M, Misch D, Berger A, Moon S, Hamilton R, Anderson J, Strickland J, Dilts V, Trueman D, Cassa G, Williams C, Holm L, Cooper S, Demming S, Richmond P, Barnes CD, Lieb D, Shaikh S, Olson J, Okun N, Davila LD, Bell G, Thornton T, Treutel J, Huertas C, Diaz C, Friedman S, Plous O, Carlton S, Blackmer K, Key J, Maldonado J, McKinney A, Walters-Treon S, Fagan D, Gregory V, Sjoblom K, Fraser-Neumann Y, Antoszyk A, Browning D, Sanders J, Brown J, Karow A, Helms J, Price A, Niemi S, Stallings A, Cowen M, Walker R, McOwen M, Lutman B, Davis L, McClain D, Clark L, Jordan D, Vittitow A, Balasubramaniam U, George R, Murphy H, Goad J, Chatari L, Brooks D, Pierce R, Hutchins R, Krug S, Bowman F, Johnson C, Mistler T, Conley N, Nelson-Parker E, Quesnelle A, Kaiser PK, Lewis H, Sears J, Holody L, Fecko T, Brugnoni N, Ross D, Allen S, Fattori A, Niskanen J, Larrison W, Falcone P, Weisz J, Griffith N, Karnolt A, Kurtz J, Ie D, Lipkowitz J, Shah K, Geraghty S, Sannazzaro B, McCall L, Harper M, Polanco-Weaver L, Napoli D, Ciardella A, Braverman J, Thomas D, Gallardo G, Dixon B, Doherty R, Stillberger M, Ryman L, Brown D, Smith C, Zapata J, Rhodes R, Fekrat S, Cooney M, Postel E, Srivastava S, Mahmoud T, Bearelly S, McCuen B, Fackler T, Mruthyunjaya P, Toth C, Jaffe G, Suner I, Gross J, O'Neal M, McClain N, Hoffmeyer G, Hawks T, Burns R, Kelly M, Lee J, Laurens A, Gammage M, Skelly M, Napoli J, Wood M, Bryant J, Poland S, Sarin N, Lansing M, Chen HZ, Fox L, Odil R, Alexander K, Smith R, Roussel D, Ross J, Elman M, Raden R, Sloan M, Starr J, Butcher T, Cain T, Sotirakos P, Andreani G, Salfer-Firestone D, Coffey T, Singletary P, Gore N, Sabates N, Sabates F, Cassell M, Poulose A, Desai K, Keeling M, Fletcher D, Gallimore G, Konior Y, Whitehead C, Kunkelman K, Sayers A, Grisafe E, Afola L, Mathura J Jr, Jones BE, Olszowy R, Mahmood Y, Zalamea J, Shekar S, Miskell B, Taylor M, Ibisevic M, Brockman N, Aberman N, Habib A, Karlsson E, Ram KC, Gauthier A, Tsong J, Rivellese M, Sharma A, Stallman J, Koh S, Lampert S, Jacobson M, Martidis A, Stoltz R, Miller John J, Hendricks S, Butler-Grant E, Marcus L, Pauley C, McManus R, Starnes C, Simpson A, Fulbright S, Kenes J, Betanzos G, Redmond M, Ellorin L, Edwards P, Ober M, Carey JD, Murphy J, Rock S, Monk M, Fletcher D, Hall J, Croswell M, Troszak T, Schillace L, Ogilvy S, Stern B, Rusinek B, Smith A, Carnegie E, Wilson D, Roberts G, Ridley M, Weidman F 3rd, Glessner A, Schafer ML, Doran S, Peterson D, Lummis J, Cisco J, Brogdon A, Pollack J, Civantos J, Ciscato B, Muir D, Mikota R, Midlock P, Kosinski B, Kourous Rezaei H, Orth D, Civantos J, Hasan S, Brown S, Townsend-Patrick S, Nelson K, Arredondo L, Lofton T, Shelton G, Figliulo C, Eliott D, Mahmoud T, Abrams G, Iezzi R, Puklin J, Tewari A, Schulz L, Randhawa S, Griffith D, Abe K, Sadikovic Z, Christopherson K, Silvis E, Morehead K, Voltz K, McDonald D, Schillace L, Bailey M, Krzeminski V, Milanovic C, Marx J, Wertz F 3rd, Blaha G, Pahk P, Barouch F, Tilton E, Stewart A, Casazza E, Selter R, Rosen J, Scrivano T, Morse PA, Kelly S Jr, Mahoney S, Concannon M, Johnson M, Rauser M, Fan J, Suthar M, Diekmann A, Chakrabarty A, Corliss C, Ortega A, Osuna S, Santiago G, Rollins K, Quesada C, Davidson C, Saldana G, Milam W, Cloud J, Kiernan W, Spaide R, Freund KB, Klancnik J, Slakter J, Sorenson J, Maranan L, Novalis C, Agresta E, Saroj N, Scolaro M, Kim J, Han D, Connor T Jr, Wirostko W, Weinberg D, Stepien K, Lange C, Drescher T, Reiter K, Alvarez D, Rekow S, Graf J, Packard K, Beringer J, Selchert K, Backes D, Keller K, Barwick V, Flanders J, Rosenthal W, Batlle I, Gerson J, Swafford L, Johnson B, Batlle K, Varner RS, Williams G, Ziolo F, Breit E, Lee D, Parks M, Maturi R, Wilson D, Hrisomalos N, Minturn J, Ciulla T, Bleau L, Steele T, Poston J, Love K, Samaniego D, Storie M, Novak C, Ghuman AT, Wing G, Walker J, Raskauskas P, Kiesel C, Knips E, Ryan C, Peters C, Dyshanowitz D, Banks J, Baumal C, Nguyen J, Duker J, Reichel E, Milch C, Rogers A, Chun D, Yates P, Eichenbaum D, Scheufele T, Wiegand T, Serfass M, Peterson T, Merry L, Snell B, Layzer J, Rosen J, Kiernan C, Thibault M, Schultz D, McMahon D, Wilson J, McDonough R, Mullen L, Rosen R, Shirkey B, Gentile R, Fitz E, Romero J, Tai K, Boyd K, Gonzalez N, Vallet N, Masini R, Kapoor S, Ovase R, Guerrero P, Joshi D, Gallardo J, Fowell S, Watson J, Cain M, Mercurio N, Gomez C, Button J, Watson E, Lyon A, Gill M, Mathura J, Mirza R, O'Donnell L, Munana A, Rozenbajgier Z, Shankle J, Ryan D, Simjanoski E, Kaminski L, Topping T, Chieh J, Morley M, Kim R, Schocket L, Chun D, Cleary T, Yates P, Eichenbaum D, Nguyen J, Wiegand T, Tyler L, Bankert J, Hurley V, Zand P, Williams L, Jones CM, Graham M, Doherty M, Marino K, Howard T, Davis H, Chong S, Corey E, Moses K, Zachariah R, Chen S, Nanda M, Maggiano J, You T, Casiano M, Buddemeier A, Vazquez A, Buddemeier A, Zimmer N, Agustin E, Agustin R, Baker C, Caldwell T, Smith D, Travis A, Lambert L, Palmer M, Martin T, Wells J, Clark WL, Spivey R, Evans M, Taylor M, Hickman A, Gridine M, McDougal P, Neely K, Gardner T, Quillen D, Scott I, Chobanoff S, Wilmarth M, Bennett T, Strong J, Walter L, Rodriguez E, Frawley M, Raja S, Larson S, Dugdale J, Lonergan K, Picchiottino R, Willman L, Khawly J, Lambert HM, Willis A, Diaz-Rohena R, Miller P, Mendenhall C, Uribe P, Busch S, Morales J, Lowd D, Schmidt A, Chase K, Miller P, Lazarte V, Fredrickson D, O'Neal M, Singerman L, Novak M, Zegarra H, Zakov ZN, Pendergast S, Miller D, Sharma M, Coney J, Schura S, Rath S, Collins J, Revella L, Stone L, Greanoff G, Dubois J, Smith-Brewer S, Cunningham T, Tanner V, DuBois K, Ilc M, Hursky J, Cunningham M, Brink T, Keller C, McNamara E, Nitzsche T, Madreperla S, Klein R, Harris M, Noorily S, Feiner L, Alworth K, Deininger D, Hetherington H, Turton E, Radzyner H, Pogosky S, McLeod K, Parke J, Irizarry V, Greenberg P, Woodcome H, Janigian R, Krzystolik M, Smith C, German E, Varadian S, DuCoty C, Hamel M, Nagle A, Banalewicz E, Salinas C, Henriques S, Jablon E, Alfaro DV, Geer B, Rodriguez E, Graterole G, Rodriguez M, Parikh N, Zapada G, McMillan R, Rothen M, Hughes M, Thompson W, Glatzer R, Lopez J, Tardif A, Fernandez C, Cousins G, Earl M, Fernandez B, McHugh K, Aramayo P, Ritchie M, Mariano J, Benton-Murray J, Rouvier G, Bolet A, Sherley C, Quinchia E, Berger B, Loose I, Rod M, Jeffers S, Durham E, Scrivner E, Nguyen L, Morris R, Manhart G, Krzykowski Q, Ostrander B, Solalinde K, Gallia B, Talbert M, Ren Y, Sun J, Callen N, Gartner M, Roth D, Green S, Leff S, Keyser B, Prenner J, Yarian D, Friedman E, Wheatley HM, Hambrock C, Tantum T, Deinzer J, LaPrise T, Anderson F, LaPrise T, Manochio M, Campanaro L, Parker S, Doft B, Freisberg L, Rath P, Lobes L, Olsen K, Reilly S, Casillo F, Depp C, Lucko N, Kulasa J, Mack B, Jones J, Campbell A, Steinberg D, Murajda-Jumba S, Latham S, Rigoni G, Wilcox L, Matthews D, Harkleroad K, Pakulski J, Borthwick AM, Hampton GR, Torrisi P, Rutled B, Spalding S 3rd, Rutledge B, Grinnell C, DiSano F, Hay P, Capone L, Burke J, Fyles K, Corey R, Harrison K, Kwasniewski L, Czajak T, Kunimoto D, Quinlan E, Sipperley J, Dugel P, Park D, Oh K, Liu J, Cornelius J, Cavanagh J, Scalzo A, Arenas S, Dawson P, Adhikari S, Bucci J, Balea G, Martin J, Jimenez N, Smith D, Doherty D, Tuttle C, Laizure B, Weckter R, Chavez M, Dunlap H, Wilson J, Bay E, Miner J, Mobley S, Lopez G, Goodart R, Faber D, Mehr D, Hurlbut-Miller P, Ahmad S, Murphy H, Gleed J, Knight D, Osguthorpe R, Perkins T, Carofanello C, Breehl B, Cleverly S, Colborn S, Farnsworth KJ, Wong K, Chen M, Niffenegger J, Levy M, Holland C, Jelemensky P, Miller R, Sneath M, Cottrill M, Hagin K, Shelton H, Brucker A, DuPont J, Nyberg W, Berger J, Weeney L, Drossner S, Metelitsina T, McRay M, Marcus D, Singh H, Benson J, Zapata G, Overton K, McAteer C, Freeman B, Cortez L, Evans M, Oldag V, Price E, Ivey K, Hendrickson J, Hill C, Coxville J, Leverett K, Chan C, Lin S, Nuthi A, Salib D, Koch W, Campbell C, Sage K, Dickerson E, Keith T, Andresen T, Wiskirchen T, Judd S, Walther K, Aldana I, Evans R, Huff K, Bretz S, Chesbrough D, Tarasewicz D, Warren S, Lehrack L, Rollins K, Castillo S, Myers L, Sun XK, Essman T, Hamlet P, McLaughlin S, Kendall B, Dorweiler E, Trythall C, Shami M, Smith S, Pusser P, Tarter C, Wentlandt T, Barragan L, Anderson E, Squires L, Bryant T, Garcia N, Callanan D, Solley W, Fish G, Creighton J, Elmore J, Grimes C, Henson M, Bradley P, Boleman B, Gray K, Bell T, Sams W, Garcia Y, Hartnett ME, Meredith T, Landers M, Garg S, Barnhart C, N'Dure F, Shields K, Esquejo-Leon R, Cantrell D, Kuppermann B, Kostamaa H, Jehan F, Hagemann L, Alexandrescu B, de Aguiar Marques L, Fardin B, Zacharias L, Huynh T, Lu S, Grijalva J, Trump B, Magallon R, Rezaei K, Mieler W, Hariprasad S, Green J, Bhatia S, Chiu E, Benevento J, Jager R, Lin R, Grassi M, Lin T, Sheth V, Strom J, Lietz F, Gen S, Marks J, Cadena I, Vernon K, Mallinga S, Pateva I, Pierce K, Lopez R, Baker A, Rago J, Sclafani L, Pimentel M, Pearson PA, Blackburn P, Reg M, Gillespie P, Hanson M, Moss P, Craig S, Drucker F, James R, Roberts L, Lewis L, Bhagat N, Zarbin M, Roy M, Ahuja R, Patel N, Garay L, Shah C, Alvir A, Elkomos G, Chin M, Fay C, Forofonova T, Malpica B, Lazar M, Oliveira A, Edema-Sillo P, Horan C, Johnson M, Elner S, Saxe S, Zacks D, Fournier L, Goings L, Hackel R, Prusak R, Gothrup J, Olsen T, Klesert T, Rath P, Terry J, Cook S, Holleschau A, Walski J, Harvey P, Cohen M, Philiph D, Patterson P, Rolfer S, Margalit E, Hejkal T, Kohlhepp M, Milleson M, Galata S, Katz A, Neely D, Eller A, Waxman E, Friberg T, Gorin M, Abdelghani W, Mack B, Fink B, Bivins F, Ostroska P, Campbell J, Lucas W, Curtin D, Murajda-Jumba S, Truman K, Owlia M, Calgaro L Jr, DiLoreto D, Chung M, O'Brien D, Fedick N, Stoutenburg A, Arcara C, Crowley G, Lafferty D, Steinmetz K, Castillo D, Fischer W, Tutko J, Grunhaus R, Smoral L, Goole M, Schaefer T, Addams L, Embrey M, Altaweel M, Nork TM, Gottlieb J, Blodi B, Chandra S, Ip M, Stevens T, Perry-Raymond J, Soderling B, Dietzman K, Krolnik D, Peterson J, Knutson G, Christianson E, Pohlman A, Somers G, Burke K, Olson M, Wealti A, Vann V, Gonzalez V, Su YT, Patel N, Chaudhry I, Herrera J, Garcia D, Gallegos S, Guel DA, Ozuna S, McNames R, Saldivar J, Corona R, Cuellar D, Garza C, Gonzalez F, Herrera A, Garcia-Garza G, Martinez M, Lopez M, Trevino M, Cantu M, Sternberg P, Recchia F, Agarwal A, Mofield G, Owings S, Taylor-Ward M, Kinder K, Lanier G, Franklin C, Adkins T, Munn GE Jr, Ladd B, Combs J, Ebert E, Sanborn G, Vaughan M, Sullivan K, Miller-Long E, Palcynski M, Zalewski M, Walsh M, Wong C, Hoyle-Harris C, Spawn K, Driver R, Ruby A, Williams G, Capone A, Hassan T, Trese M, Garretson B, Yedavally S, Regan V, DuLong C, Bridges C, Medina T, Treuter T, Guenther M, McIver F, Roberts P, Consolo C, Zajechowski M, Staples L, Brown D, Wong T, Fish R, Kim R, Benz M, Chen E, Hallett J, Tang XS, Hutchison C, De La Garza R, Jasso L, Strickler A, Norris Jennifer, Rodriguez M, Garcia L, Shawver L, Kegley E, Williamson A, Johnstone L, Skelly M, Evans M, Bui H, Richter B, Mutz K, Kimbrough A, Hay Shayla A, Kubecka D, Goates D, McGilvra S, Dev S, Ramsay R, Ryan E, Williams D, Mittra R, Cantrill H, Johnson J, Bennett S, Quiram P, Oestreich N, Enloe J, Cheshier H, Gamblain J, Erickson D, Jones T, Follano G, Moos M, Neist R, Hodgden K, Mayleben L, Schindledecker S, Greven C, Slusher MM, Fish J, Tyler M, Miller D, Clark M, Ledbetter F, Everhart C, Cooke L, Jumper JM, McDonald HR, Ai E, Johnson R, Yang S, Fu A, Teske B, Huggans S, Miller J, Grout S, Esquejo RL, Bye A, Ryan D, Stolarczuk M, Linares S, Patel S, Lee SY, Dunn B, Garcia K, Varnadore L, Arrington B, Jones T, Adams L, Jaimes A, McArthur M, Gwyn Nafe M, Bartlett T, Nguyen Q, Solomon S, Haller J, Schachat A, Zimmer-Galler I, Handa J, Bressler S, Gehlbach P, Finkelstein D, Sung J, Goldberg M, Campochiaro P, Shaikh O, LeBow A, Klima K, Henson H, Baird A, Belt J, McDonald J, Herring M, Emmert D, Falk R, Cain D, Shah SM, Grawl J, Simmons-Denton J, Singletary P, Greer L.

Author information

  • 1EMMES Corporation, Rockville, MD 20850, USA.

Erratum in

  • Arch Ophthalmol. 2009 Dec;127(12):1655.

Abstract

OBJECTIVE:

To compare the efficacy and safety of 1-mg and 4-mg doses of preservative-free intravitreal triamcinolone with standard care (grid photocoagulation in eyes without dense macular hemorrhage and deferral of photocoagulation until hemorrhage clears in eyes with dense macular hemorrhage) for eyes with vision loss associated with macular edema secondary to branch retinal vein occlusion (BRVO).

METHODS:

Multicenter, randomized clinical trial of 411 participants. Main Outcome Measure Gain in visual acuity letter score of 15 or more from baseline to month 12.

RESULTS:

Twenty-nine percent, 26%, and 27% of participants achieved the primary outcome in the standard care, 1-mg, and 4-mg groups, respectively. None of the pairwise comparisons between the 3 groups was statistically significant at month 12. The rates of elevated intraocular pressure and cataract were similar for the standard care and 1-mg groups, but higher in the 4-mg group.

CONCLUSIONS:

There was no difference identified in visual acuity at 12 months for the standard care group compared with the triamcinolone groups; however, rates of adverse events (particularly elevated intraocular pressure and cataract) were highest in the 4-mg group. Application to Clinical Practice Grid photocoagulation as applied in the SCORE Study remains the standard care for patients with vision loss associated with macular edema secondary to BRVO who have characteristics similar to participants in the SCORE-BRVO trial. Grid photocoagulation should remain the benchmark against which other treatments are compared in clinical trials for eyes with vision loss associated with macular edema secondary to BRVO. Trial Registration clinicaltrials.gov Identifier: NCT00105027.

Comment in

PMID:
19752420
[PubMed - indexed for MEDLINE]
PMCID:
PMC2806600
Free PMC Article

Images from this publication.See all images (3)Free text

Figure 1
Figure 2
Figure 3
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems Icon for PubMed Central
    Loading ...
    Write to the Help Desk