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Arch Ophthalmol. 2009 Sep;127(9):1101-14. doi: 10.1001/archophthalmol.2009.234.

A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with observation to treat vision loss associated with macular edema secondary to central retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study report 5.

Collaborators (1292)

Ip MS, Fisher M, Nardi B, Cahill NT, Scott IU, VanVeldhuisen PC, Oden NL, Figueroa MJ, Charlton A, Guan E, Moreno O, Van Dyke J, Bailey T, Robinson C, Frasketi M, Blodi BA, Christianson DJ, Elledge J, Gama V, Glander KE, Goulding A, Myers DJ, Reed SB, Vargo P, Warren KJ, Redford M, Blodi BA, Figueroa MJ, Ip MS, Oden NL, Redford M, Scott IU, VanVeldhuisen PC, Jumper JM, Oestreich N, Connett JC, Blodi BA, Blumenkranz MS, Bressler NM, Csaky K, Davis MD, Gorin M, Haller JA, Ip MS, Johnson MW, Lindblad A, Doft BH, Fekrat S, Figueroa MJ, Finkelstein D, Oden NL, Redford M, Scott IU, VanVeldhuisen PC, Schwartz J, Rial J, Adams J, Farlow B, Lincoln P, Farrell H, Phoebus J, Shah G, Blinder K, Engelbrech N, Thomas M, Joseph D, Holekamp N, Weeks R, Light P, Wehmeier J, Raeber M, Wright T, Nobel V, Boyd L, Walters C, Ressel T, Ray S, Verne A, Leong C, Daniels S, Ting TD, Dowell K, Aguilos M, Moreci C, Hanamoto F, Williams M, Takahara S, Tejada R, Combs W, Teshima-McCormick S, Pieramici D, Nasir M, Avery R, Castellarin A, See R, Couvillion S, Robbins E, Norton T, Davies S, Turner J, Cook S, Basefsky J, Smith R, Tramel L, Guist M, Kruzel M, Boyer K, Sterling A, Avery K, Magana L, Mincey G, Schafer ML, Fleming J, Fulghum L, McVerry W, Pierce SJ, Taylor AK, Coley T, West M, Cole M, Dick J, Gross J, Fishburne B, Magee M, Enlow J, Cummings P, Flowers A, Bequette C, Henry K, Price R, Purvis H, Christoff R, Hoerner S, Hawkins H, Lovit H, Fore C, Gabriel R, Bland K, Lauer A, Hwang T, Wilson D, Stout JT, Flaxel C, Pope S, Martin D, Lundquist A, West K, Rossi J, Pickell S, Gaultney J, Wallace P, Redenbo E, Howell C, Steinkamp P, Rice P, Toomey M, Nolte S, Hanel S, Vahrenwald D, Ira S, Indermill C, Tolentino M, Misch D, Berger A, Moon S, Hamilton R, Anderson J, Strickland J, Dilts V, Trueman D, Cassa G, Williams C, Holm L, Cooper S, Demming S, Richmond P, Barnes CD, Lieb D, Shaikh S, Olson J, Okun N, Davila LD, Bell G, Thornton T, Treutel J, Huertas C, Diaz C, Friedman S, Plous O, Carlton S, Blackmer K, Key J, Maldonado J, McKinney A, Walters-Treon S, Fagan D, Gregory V, Sjoblom K, Fraser-Neumann Y, Antoszyk A, Browning D, Sanders J, Brown J, Karow A, Helms J, Price A, Niemi S, Stallings A, Cowen M, Walker R, McOwen M, Lutman B, Davis L, McClain D, Clark L, Jordan D, Vittitow A, Balasubramaniam U, George R, Murphy H, Goad J, Chatari L, Brooks D, Pierce R, Hutchins R, Krug S, Bowman F, Johnson C, Mistler T, Conley N, Nelson-Parker E, Quesnelle A, Kaiser PK, Lewis H, Sears J, Holody L, Fecko T, Brugnoni N, Ross D, Allen S, Fattori A, Niskanen J, Larrison W, Falcone P, Weisz J, Griffith N, Karnolt A, Kurtz J, Ie D, Lipkowitz J, Shah K, Geraghty S, Sannazzaro B, McCall L, Harper M, Polanco-Weaver L, Napoli D, Ciardella A, Braverman J, Thomas D, Gallardo G, Dixon B, Doherty R, Stillberger M, Ryman L, Brown D, Smith C, Zapata J, Rhodes R, Fekrat S, Cooney M, Postel E, Srivastava S, Mahmoud T, Bearelly S, McCuen B, Fackler T, Mruthyunjaya P, Toth C, Jaffe G, Suner I, Gross J, O'Neal M, McClain N, Hoffmeyer G, Hawks T, Burns R, Kelly M, Lee J, Laurens A, Gammage M, Skelly M, Napoli J, Wood M, Bryant J, Poland S, Sarin N, Lansing M, Chen HZ, Fox L, Odil R, Alexander K, Smith R, Roussel D, Ross J, Elman M, Raden R, Sloan M, Starr J, Butcher T, Cain T, Sotirakos P, Andreani G, Salfer-Firestone D, Coffey T, Singletary P, Gore N, Sabates N, Sabates F, Cassell M, Poulose A, Desai K, Keeling M, Fletcher D, Gallimore G, Konior Y, Whitehead C, Kunkelman K, Sayers A, Grisafe E, Afola L, Mathura J Jr, Jones BE, Olszowy R, Mahmood Y, Zalamea J, Shekar S, Miskell B, Taylor M, Ibisevic M, Brockman N, Aberman N, Habib A, Karlsson E, Ram KC, Gauthier A, Tsong J, Rivellese M, Sharma A, Stallman J, Koh S, Lampert S, Jacobson M, Martidis A, Stoltz R, Miller J, Hendricks S, Butler-Grant E, Marcus L, Pauley C, McManus R, Starnes C, Simpson A, Fulbright S, Kenes J, Betanzos G, Redmond M, Ellorin L, Edwards P, Ober M, Carey JD, Murphy J, Rock S, Monk M, Fletcher D, Hall J, Croswell M, Troszak T, Schillace L, Ogilvy S, Stern B, Rusinek B, Smith A, Carnegie E, Wilson D, Roberts G, Ridley M, Weidman F 3rd, Glessner A, Schafer ML, Doran S, Peterson D, Lummis J, Cisco J, Brogdon A, Pollack J, Civantos J, Ciscato B, Muir D, Mikota R, Midlock P, Kosinski B, Kourous Rezaei H, Orth D, Civantos J, Hasan S, Brown S, Townsend-Patrick S, Nelson K, Arredondo L, Lofton T, Shelton G, Figliulo C, Eliott D, Mahmoud T, Abrams G, Iezzi R, Puklin J, Tewari A, Schulz L, Randhawa S, Griffith D, Abe K, Sadikovic Z, Christopherson K, Silvis E, Morehead K, Voltz K, McDonald D, Schillace L, Bailey M, Krzeminski V, Milanovic C, Marx J, Wertz F 3rd, Blaha G, Pahk P, Barouch F, Tilton E, Stewart A, Casazza E, Selter R, Rosen J, Scrivano T, Morse PA, Kelly S Jr, Mahoney S, Concannon M, Johnson M, Rauser M, Fan J, Suthar M, Diekmann A, Chakrabarty A, Corliss C, Ortega A, Osuna S, Santiago G, Rollins K, Quesada C, Davidson C, Saldana G, Milam W, Cloud J, Kiernan W, Spaide R, Freund KB, Klancnik J, Slakter J, Sorenson J, Maranan L, Novalis C, Agresta E, Saroj N, Scolaro M, Kim J, Han D, Connor T Jr, Wirostko W, Weinberg D, Stepien K, Lange C, Drescher T, Reiter K, Alvarez D, Rekow S, Graf J, Packard K, Beringer J, Selchert K, Backes D, Keller K, Barwick V, Flanders J, Rosenthal W, Batlle I, Gerson J, Swafford L, Johnson B, Batlle K, Varner RS, Williams G, Ziolo F, Breit E, Lee D, Parks M, Maturi R, Wilson D, Hrisomalos N, Minturn J, Ciulla T, Bleau L, Steele T, Poston J, Love K, Samaniego D, Storie M, Novak C, Ghuman AT, Wing G, Walker J, Raskauskas P, Kiesel C, Knips E, Ryan C, Peters C, Dyshanowitz D, Banks J, Baumal C, Nguyen J, Duker J, Reichel E, Milch C, Rogers A, Chun D, Yates P, Eichenbaum D, Scheufele T, Wiegand T, Serfass M, Peterson T, Merry L, Snell B, Layzer J, Rosen J, Kiernan C, Thibault M, Schultz D, McMahon D, Wilson J, McDonough R, Mullen L, Rosen R, Shirkey B, Gentile R, Fitz E, Romero J, Tai K, Boyd K, Gonzalez N, Vallet N, Masini R, Kapoor S, Ovase R, Guerrero P, Joshi D, Gallardo J, Fowell S, Watson J, Cain M, Mercurio N, Gomez C, Button J, Watson E, Lyon A, Gill M, Mathura J, Mirza R, O'Donnell L, Munana A, Rozenbajgier Z, Shankle J, Ryan D, Simjanoski E, Kaminski L, Topping T, Chieh J, Morley M, Kim R, Schocket L, Chun D, Cleary T, Yates P, Eichenbaum D, Nguyen J, Wiegand T, Tyler L, Bankert J, Hurley V, Zand P, Williams L, Jones CM, Graham M, Doherty M, Marino K, Howard T, Davis H, Chong S, Corey E, Moses K, Zachariah R, Chen S, Nanda M, Maggiano J, You T, Casiano M, Buddemeier A, Vazquez A, Buddemeier A, Zimmer N, Agustin E, Agustin R, Baker C, Caldwell T, Smith D, Travis A, Lambert L, Palmer M, Martin T, Wells J, Clark WL, Spivey R, Evans M, Taylor M, Hickman A, Gridine M, McDougal P, Neely K, Gardner T, Quillen D, Scott I, Chobanoff S, Wilmarth M, Bennett T, Strong J, Walter L, Rodriguez E, Frawley M, Raja S, Larson S, Dugdale J, Lonergan K, Picchiottino R, Willman L, Khawly J, Lambert HM, Willis A, Diaz-Rohena R, Miller P, Mendenhall C, Uribe P, Busch S, Morales J, Lowd D, Schmidt A, Chase K, Miller P, Lazarte V, Fredrickson D, O'Neal M, Singerman L, Novak M, Zegarra H, Zakov ZN, Pendergast S, Miller D, Sharma M, Coney J, Schura S, Rath S, Collins J, Revella L, Stone L, Greanoff G, Dubois J, Smith-Brewer S, Cunningham T, Tanner V, DuBois K, Ilc M, Hursky J, Cunningham M, Brink T, Keller C, McNamara E, Nitzsche T, Madreperla S, Klein R, Harris M, Noorily S, Feiner L, Alworth K, Deininger D, Hetherington H, Turton E, Radzyner H, Pogosky S, McLeod K, Parke J, Irizarry V, Greenberg P, Woodcome H, Janigian R, Krzystolik M, Smith C, German E, Varadian S, DuCoty C, Hamel M, Nagle A, Banalewicz E, Salinas C, Henriques S, Jablon E, Alfaro DV, Geer B, Rodriguez E, Graterole G, Rodriguez M, Parikh N, Zapada G, McMillan R, Rothen M, Hughes M, Thompson W, Glatzer R, Lopez J, Tardif A, Fernandez C, Cousins G, Earl M, Fernandez B, McHugh K, Aramayo P, Ritchie M, Mariano J, Benton-Murray J, Rouvier G, Bolet A, Sherley C, Quinchia E, Berger B, Loose I, Rod M, Jeffers S, Durham E, Scrivner E, Nguyen L, Morris R, Manhart G, Krzykowski Q, Ostrander B, Solalinde K, Gallia B, Talbert M, Ren Y, Sun J, Callen N, Gartner M, Roth D, Green S, Leff S, Keyser B, Prenner J, Yarian D, Friedman E, Wheatley HM, Hambrock C, Tantum T, Deinzer J, LaPrise T, Anderson F, LaPrise T, Manochio M, Campanaro L, Parker S, Doft B, Freisberg L, Rath P, Lobes L, Olsen K, Reilly S, Casillo F, Depp C, Lucko N, Kulasa J, Mack B, Jones J, Campbell A, Steinberg D, Murajda-Jumba S, Latham S, Rigoni G, Wilcox L, Matthews D, Harkleroad K, Pakulski J, Borthwick AM, Hampton GR, Torrisi P, Rutled B, Spalding S 3rd, Rutledge B, Grinnell C, DiSano F, Hay P, Capone L, Burke J, Fyles K, Corey R, Harrison K, Kwasniewski L, Czajak T, Kunimoto D, Quinlan E, Sipperley J, Dugel P, Park D, Oh K, Liu J, Cornelius J, Cavanagh J, Scalzo A, Arenas S, Dawson P, Adhikari S, Bucci J, Balea G, Martin J, Jimenez N, Smith D, Doherty D, Tuttle C, Laizure B, Weckter R, Chavez M, Dunlap H, Wilson J, Bay E, Miner J, Mobley S, Lopez G, Goodart R, Faber D, Mehr D, Hurlbut-Miller P, Ahmad S, Murphy H, Gleed J, Knight D, Osguthorpe R, Perkins T, Carofanello C, Breehl B, Cleverly S, Colborn S, Farnsworth KJ, Wong K, Chen M, Niffenegger J, Levy M, Holland C, Jelemensky P, Miller R, Sneath M, Cottrill M, Hagin K, Shelton H, Brucker A, DuPont J, Nyberg W, Berger J, Weeney L, Drossner S, Metelitsina T, McRay M, Marcus D, Singh H, Benson J, Zapata G, Overton K, McAteer C, Freeman B, Cortez L, Evans M, Oldag V, Price E, Ivey K, Hendrickson J, Hill C, Coxville J, Leverett K, Chan C, Lin S, Nuthi A, Salib D, Koch W, Campbell C, Sage K, Dickerson E, Keith T, Andresen T, Wiskirchen T, Judd S, Walther K, Aldana I, Evans R, Huff K, Bretz S, Chesbrough D, Tarasewicz D, Warren S, Lehrack L, Rollins K, Castillo S, Myers L, Sun XK, Essman T, Hamlet P, McLaughlin S, Kendall B, Dorweiler E, Trythall C, Shami M, Smith S, Pusser P, Tarter C, Wentlandt T, Barragan L, Anderson E, Squires L, Bryant T, Garcia N, Callanan D, Solley W, Fish G, Creighton J, Elmore J, Grimes C, Henson M, Bradley P, Boleman B, Gray K, Bell T, Sams W, Garcia Y, Hartnett ME, Meredith T, Landers M, Garg S, Barnhart C, N'Dure F, Shields K, Esquejo-Leon R, Cantrell D, Kuppermann B, Kostamaa H, Jehan F, Hagemann L, Alexandrescu B, de Aguiar Marques L, Fardin B, Zacharias L, Huynh T, Lu S, Grijalva J, Trump B, Magallon R, Rezaei K, Mieler W, Hariprasad S, Green J, Bhatia S, Chiu E, Benevento J, Jager R, Lin R, Grassi M, Lin T, Sheth V, Strom J, Lietz F, Gen S, Marks J, Cadena I, Vernon K, Mallinga S, Pateva I, Pierce K, Lopez R, Baker A, Rago J, Sclafani L, Pimentel M, Pearson PA, Blackburn P, Reg M, Gillespie P, Hanson M, Moss P, Craig S, Drucker F, James R, Roberts L, Lewis L, Bhagat N, Zarbin M, Roy M, Ahuja R, Patel N, Garay L, Shah C, Alvir A, Elkomos G, Chin M, Fay C, Forofonova T, Malpica B, Lazar M, Oliveira A, Edema-Sillo P, Horan C, Johnson M, Elner S, Saxe S, Zacks D, Fournier L, Goings L, Hackel R, Prusak R, Gothrup J, Olsen T, Klesert T, Rath P, Terry J, Cook S, Holleschau A, Walski J, Harvey P, Cohen M, Philiph D, Patterson P, Rolfer S, Margalit E, Hejkal T, Kohlhepp M, Milleson M, Galata S, Katz A, Neely D, Eller A, Waxman E, Friberg T, Gorin M, Abdelghani W, Mack B, Fink B, Bivins F, Ostroska P, Campbell J, Lucas W, Curtin D, Murajda-Jumba S, Truman K, Owlia M, Calgaro L, DiLoreto D Jr, Chung M, O'Brien D, Fedick N, Stoutenburg A, Arcara C, Crowley G, Lafferty D, Steinmetz K, Castillo D, Fischer W, Tutko J, Grunhaus R, Smoral L, Goole M, Schaefer T, Addams L, Embrey M, Altaweel M, Nork TM, Gottlieb J, Blodi B, Chandra S, Ip M, Stevens T, Perry-Raymond J, Soderling B, Dietzman K, Krolnik D, Peterson J, Knutson G, Christianson E, Pohlman A, Somers G, Burke K, Olson M, Wealti A, Vann V, Gonzalez V, Su YT, Patel N, Chaudhry I, Herrera J, Garcia D, Gallegos S, Guel DA, Ozuna S, McNames R, Saldivar J, Corona R, Cuellar D, Garza C, Gonzalez F, Herrera A, Garcia-Garza G, Martinez M, Lopez M, Trevino M, Cantu M, Sternberg P, Recchia F, Agarwal A, Mofield G, Owings S, Taylor-Ward M, Kinder K, Lanier G, Franklin C, Adkins T, Munn GE Jr, Ladd B, Combs J, Ebert E, Sanborn G, Vaughan M, Sullivan K, Miller-Long E, Palcynski M, Zalewski M, Walsh M, Wong C, Hoyle-Harris C, Spawn K, Driver R, Ruby A, Williams G, Capone A, Hassan T, Trese M, Garretson B, Yedavally S, Regan V, DuLong C, Bridges C, Medina T, Treuter T, Guenther M, McIver F, Roberts P, Consolo C, Zajechowski M, Staples L, Brown D, Wong T, Fish R, Kim R, Benz M, Chen E, Hallett J, Tang XS, Hutchison C, De La Garza R, Jasso L, Strickler A, Norris J, Rodriguez M, Garcia L, Shawver L, Kegley E, Williamson A, Johnstone L, Skelly M, Evans M, Bui H, Richter B, Mutz K, Kimbrough A, Hay S, Kubecka D, Goates D, McGilvra S, Dev S, Ramsay R, Ryan E, Williams D, Mittra R, Cantrill H, Johnson J, Bennett S, Quiram P, Oestreich N, Enloe J, Cheshier H, Gamblain J, Erickson D, Jones T, Follano G, Moos M, Neist R, Hodgden K, Mayleben L, Schindledecker S, Greven C, Slusher MM, Fish J, Tyler M, Miller D, Clark M, Ledbetter F, Everhart C, Cooke L, Jumper JM, McDonald HR, Ai E, Johnson R, Yang S, Fu A, Teske B, Huggans S, Miller J, Grout S, Esquejo RL, Bye A, Ryan D, Stolarczuk M, Linares S, Patel S, Lee SY, Dunn B, Garcia K, Varnadore L, Arrington B, Jones T, Adams L, Jaimes A, McArthur M, Gwyn Nafe M, Bartlett T, Nguyen Q, Solomon S, Haller J, Schachat A, Zimmer-Galler I, Handa J, Bressler S, Gehlbach P, Finkelstein D, Sung J, Goldberg M, Campochiaro P, Shaikh O, LeBow A, Klima K, Henson H, Baird A, Belt J, McDonald J, Herring M, Emmert D, Falk R, Cain D, Shah SM, Grawl J, Simmons-Denton J, Singletary P, Greer L.

Author information

  • 1EMMES Corporation, Rockville, MD 20850, USA.

Erratum in

  • Arch Ophthalmol. 2009 Dec;127(12):1648.

Abstract

OBJECTIVE:

To compare the efficacy and safety of 1-mg and 4-mg doses of preservative-free intravitreal triamcinolone with observation for eyes with vision loss associated with macular edema secondary to perfused central retinal vein occlusion (CRVO).

METHODS:

Multicenter, randomized, clinical trial of 271 participants.

MAIN OUTCOME MEASURE:

Gain in visual acuity letter score of 15 or more from baseline to month 12.

RESULTS:

Seven percent, 27%, and 26% of participants achieved the primary outcome in the observation, 1-mg, and 4-mg groups, respectively. The odds of achieving the primary outcome were 5.0 times greater in the 1-mg group than the observation group (odds ratio [OR], 5.0; 95% confidence interval [CI], 1.8-14.1; P = .001) and 5.0 times greater in 4-mg group than the observation group (OR, 5.0; 95% CI, 1.8-14.4; P = .001); there was no difference identified between the 1-mg and 4-mg groups (OR, 1.0; 95% CI, 0.5-2.1; P = .97). The rates of elevated intraocular pressure and cataract were similar for the observation and 1-mg groups, but higher in the 4-mg group.

CONCLUSIONS:

Intravitreal triamcinolone is superior to observation for treating vision loss associated with macular edema secondary to CRVO in patients who have characteristics similar to those in the SCORE-CRVO trial. The 1-mg dose has a safety profile superior to that of the 4-mg dose. Application to Clinical Practice Intravitreal triamcinolone in a 1-mg dose, following the retreatment criteria applied in the SCORE Study, should be considered for up to 1 year, and possibly 2 years, for patients with characteristics similar to those in the SCORE-CRVO trial. Trial Registration clinicaltrials.gov Identifier: NCT00105027.

Comment in

PMID:
19752419
[PubMed - indexed for MEDLINE]
PMCID:
PMC2872173
Free PMC Article

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