Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Contraception. 2009 Oct;80(4):372-80. doi: 10.1016/j.contraception.2009.04.010. Epub 2009 Jun 10.

Oral contraceptives and family history of breast cancer.

Author information

  • 1Department of Reproductive Health and Research, World Health Organization, 1211 Geneva 27, Switzerland. gaffieldm@who.int

Abstract

BACKGROUND:

Questions remain regarding whether oral contraceptive (OC) use among women with a family history of breast cancer increases disease risk.

STUDY DESIGN:

We conducted a systematic review by searching MEDLINE and CENTRAL databases for evidence (in all languages) published in peer-reviewed journals from 1966 to July 2008 that provided estimates of breast cancer risk according to family history. Twelve articles were identified and the quality of each study was assessed using the United States Preventive Services Task Force grading system.

RESULTS:

Results from 10 studies and one pooled analysis of 54 studies suggest that the use of OCs does not significantly modify the risk of breast cancer among women with a familial history of breast cancer; however, evidence from four studies shows that some women may be at a greater risk, particularly women who took OCs prior to 1975.

CONCLUSIONS:

Current evidence shows that women with a family history of breast cancer do not increase their disease risk by using OCs.

PMID:
19751860
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk