Neurosci Lett. 2009 Dec 4;466(2):89-98. Epub 2009 Sep 12.

Enhancing non-coding RNA information content with ADAR editing.

Source

Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA.

Abstract

The depth and complexity of the non-coding transcriptome in nervous system tissues provides a rich substrate for adenosine de-amination acting on RNA (ADAR). Non-coding RNAs (ncRNAs) serve diverse regulatory and computational functions, coupling signal flow from the environment to evolutionarily coded analog and digital information elements within the transcriptome. We present a perspective of ADARs interaction with the non-coding transcriptome as a computational matrix, enhancing the information processing power of the cell, adding flexibility, rapid response, and fine tuning to critical pathways. Dramatic increases in ADAR activity during stress response and inflammation result in powerful information processing events that change the functional state of the cell. This review examines the pathways and mechanisms of ADAR interaction with the non-coding transcriptome, and their functional consequences for information processing in nervous system tissues.

PMID:: 19751800; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Adenosine - HSDB

Supplemental Content

Save items

Related citations in PubMed

Review Origins and evolution of ADAR-mediated RNA editing. [IUBMB Life. 2009]
Review Origins and evolution of ADAR-mediated RNA editing.
Jin Y, Zhang W, Li Q. IUBMB Life. 2009 Jun; 61(6):572-8.
Editing independent effects of ADARs on the miRNA/siRNA pathways. [EMBO J. 2009]
Editing independent effects of ADARs on the miRNA/siRNA pathways.
Heale BS, Keegan LP, McGurk L, Michlewski G, Brindle J, Stanton CM, Caceres JF, O'Connell MA. EMBO J. 2009 Oct 21; 28(20):3145-56. Epub 2009 Aug 27.
Review Adenosine-to-inosine RNA editing. [Wiley Interdiscip Rev Syst Bio...]
Review Adenosine-to-inosine RNA editing.
Zinshteyn B, Nishikura K. Wiley Interdiscip Rev Syst Biol Med. 2009 Sep-Oct; 1(2):202-9.
Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) targets. [J Biol Chem. 2011]
Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) targets.
Jepson JE, Savva YA, Yokose C, Sugden AU, Sahin A, Reenan RA. J Biol Chem. 2011 Mar 11; 286(10):8325-37. Epub 2010 Nov 15.
Tuning of RNA editing by ADAR is required in Drosophila. [EMBO J. 2005]
Tuning of RNA editing by ADAR is required in Drosophila.
Keegan LP, Brindle J, Gallo A, Leroy A, Reenan RA, O'Connell MA. EMBO J. 2005 Jun 15; 24(12):2183-93. Epub 2005 May 26.

See reviews... See all...

Cited by 3 PubMed Central articles

Identification of widespread ultra-edited human RNAs. [PLoS Genet. 2011]
Identification of widespread ultra-edited human RNAs.
Carmi S, Borukhov I, Levanon EY. PLoS Genet. 2011 Oct; 7(10):e1002317. Epub 2011 Oct 20.
Competition between ADAR and RNAi pathways for an extensive class of RNA targets. [Nat Struct Mol Biol. 2011]
Competition between ADAR and RNAi pathways for an extensive class of RNA targets.
Wu D, Lamm AT, Fire AZ. Nat Struct Mol Biol. 2011 Sep 11; 18(10):1094-101. Epub 2011 Sep 11.
Review Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral. [Virology. 2011]
Review Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral.
Samuel CE. Virology. 2011 Mar 15; 411(2):180-93. Epub 2011 Jan 5.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Enhancing non-coding RNA information content with ADAR editing.
Enhancing non-coding RNA information content with ADAR editing.
Neurosci Lett. 2009 Dec 4 ;466(2):89-98. Epub 2009 Sep 12 .

PubMed
CD8+ lymphocytes from patients with systemic lupus erythematosus sustain, rather...
CD8+ lymphocytes from patients with systemic lupus erythematosus sustain, rather than suppress, spontaneous polyclonal IgG production and synergize with CD4+ cells to support autoantibody synthesis.
Arthritis Rheum. 1990 Aug ;33(8):1216-25.

PubMed
Neighborhood SES and walkability are related to physical activity behavior in Be...
Neighborhood SES and walkability are related to physical activity behavior in Belgian adults.
Prev Med. 2010 Jan ;50 Suppl 1:S74-9. Epub 2009 Sep 12 .

PubMed
eIF1 controls multiple steps in start codon recognition during eukaryotic transl...
eIF1 controls multiple steps in start codon recognition during eukaryotic translation initiation.
J Mol Biol. 2009 Nov 27 ;394(2):268-85. Epub 2009 Sep 12 .

PubMed
Risk factors for onset of osteoarthritis of the knee in older adults: a systemat...
Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis.
Osteoarthritis Cartilage. 2010 Jan ;18(1):24-33. Epub 2009 Sep 2 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: