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Helicobacter. 2009 Oct;14(5):120-5. doi: 10.1111/j.1523-5378.2009.00708.x.

Genetic variation in a4GnT in relation to Helicobacter pylori serology and gastric cancer risk.

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  • 1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Abstract

BACKGROUND:

Helicobacter pylori, a known risk factor of gastric cancer, rarely colonize the deeper portion of normal gastric glands, where the mucus is rich in alpha-1,4-linked N-acetylglucosamine capped O-glycans, that strongly inhibit H. pylori growth in vitro.

MATERIALS AND METHODS:

We investigated the association between genetic variation in the O-glycan transferase encoding gene (a4GnT) and H. pylori infection and gastric cancer risk using a Polish population-based case-control study (273 gastric cancer patients and 377 controls).

RESULTS:

A haplotype at the rs2622694-rs397266 locus was associated with H. pylori infection, with the A-A haplotype associated with a higher risk compared with the most frequent G-G haplotype (odds ratio 2.30; 95% confidence interval 1.35-3.92). The association remained significant after correction for multiple tests (global p value: nominal 0.002, empirical 0.045). Neither this haplotype nor the tagSNPs were associated with overall gastric cancer risk.

CONCLUSION:

a4GnT genetic variation may be relevant to H. pylori infection, but not to gastric cancer risk.

PMID:
19751437
[PubMed - indexed for MEDLINE]
PMCID:
PMC3008782
Free PMC Article
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