Format

Send to

Choose Destination
See comment in PubMed Commons below
Br J Pharmacol. 2009 Apr;156(8):1196-203. doi: 10.1111/j.1476-5381.2009.00131.x.

New tricks for old dogs: KCNQ expression and role in smooth muscle.

Author information

  • 1Division of Basic Medical Sciences, St George's, University of London, London, UK. i.greenwood@sgul.ac.uk

Abstract

Ion channels encoded by the KCNQ gene family (K(v)7.1-7.5) are major determinants of neuronal membrane potential and the cardiac action potential. This key physiological role is highlighted by the existence of a number of hereditary disorders caused by mutations to KCNQ genes. Recently, KCNQ gene expression has been identified in vascular and non-vascular smooth muscles. In addition, experiments with an array of pharmacological modulators of KCNQ channels have supported a crucial role for these channels in regulating smooth muscle contractility. This article will provide an overview of present understanding in this nascent area of KCNQ research and will offer guidance as to future directions.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Write to the Help Desk