Lancet. 1990 Sep 1;336(8714):545-9.

Life-threatening bacteraemia in HIV-1 seropositive adults admitted to hospital in Nairobi, Kenya.

Gilks CF, Brindle RJ, Otieno LS, Simani PM, Newnham RS, Bhatt SM, Lule GN, Okelo GB, Watkins WM, Waiyaki PG, et al.

Source

Clinical Research Centre, Kenya Medical Research Institute, Nairobi.

Abstract

During 6 months, 506 consecutive adult emergency admissions to hospital in Nairobi were enrolled in a study of bacteraemia and HIV infection. 19% were HIV-1 antibody positive. Significantly more HIV-seropositive than seronegative patients had bacteraemia (26% vs 6%). The predominant organisms isolated from the seropositive patients were Salmonella typhimurium and Streptococcus pneumoniae. Mortality was higher in the seropositive than in the seronegative bacteraemic patients. The findings suggest that non-opportunistic bacteria are important causes of morbidity and mortality in HIV-infected individuals in Africa.

Comment in

Lancet. 1990 Oct 6;336(8719):877-8.

PMID:: 1975046; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Grant Support

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Grant Support

Wellcome Trust/United Kingdom

LinkOut - more resources

Medical

Supplemental Content

Related citations

The impact of HIV on Streptococcus pneumoniae bacteraemia in a South African population. [AIDS. 1998]
The impact of HIV on Streptococcus pneumoniae bacteraemia in a South African population.
Jones N, Huebner R, Khoosal M, Crewe-Brown H, Klugman K. AIDS. 1998 Nov 12; 12(16):2177-84.
A prospective study of community-acquired bloodstream infections among febrile adults admitted to Mulago Hospital in Kampala, Uganda. [J Acquir Immune Defic Syndr Hum Retrovirol....]
A prospective study of community-acquired bloodstream infections among febrile adults admitted to Mulago Hospital in Kampala, Uganda.
Ssali FN, Kamya MR, Wabwire-Mangen F, Kasasa S, Joloba M, Williams D, Mugerwa RD, Ellner JJ, Johnson JL. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 15; 19(5):484-9.
Infection and morbidity in patients with tuberculosis in Nairobi, Kenya. [AIDS. 1993]
Infection and morbidity in patients with tuberculosis in Nairobi, Kenya.
Brindle RJ, Nunn PP, Batchelor BI, Gathua SN, Kimari JN, Newnham RS, Waiyaki PG. AIDS. 1993 Nov; 7(11):1469-74.
Review Natural history and spectrum of disease in adults with HIV/AIDS in Africa. [AIDS. 1997]
Review Natural history and spectrum of disease in adults with HIV/AIDS in Africa.
Grant AD, Djomand G, De Cock KM. AIDS. 1997; 11 Suppl B:S43-54.
Review Non-opportunistic bacterial infections in HIV-seropositive adults in Nairobi, Kenya. [AIDS. 1991]
Review Non-opportunistic bacterial infections in HIV-seropositive adults in Nairobi, Kenya.
Gilks CF, Ojoo SA, Brindle RJ. AIDS. 1991; 5 Suppl 1:S113-6.

See reviews... See all...

Cited by 31 PubMed Central articles

Antimicrobial therapy for the treatment of opportunistic infections in HIV/AIDS patients: a critical appraisal. [HIV AIDS (Auckl). 2011]
Antimicrobial therapy for the treatment of opportunistic infections in HIV/AIDS patients: a critical appraisal.
Seddon J, Bhagani S. HIV AIDS (Auckl). 2011; 3:19-33. Epub 2011 Apr 4.
The Role of the spv Genes in Salmonella Pathogenesis. [Front Microbiol. 2011]
The Role of the spv Genes in Salmonella Pathogenesis.
Guiney DG, Fierer J. Front Microbiol. 2011; 2:129. Epub 2011 Jun 14.
Whole-genome analysis of Salmonella enterica serovar Typhimurium T000240 reveals the acquisition of a genomic island involved in multidrug resistance via IS1 derivatives on the chromosome. [Antimicrob Agents Chemother. 2011]
Whole-genome analysis of Salmonella enterica serovar Typhimurium T000240 reveals the acquisition of a genomic island involved in multidrug resistance via IS1 derivatives on the chromosome.
Izumiya H, Sekizuka T, Nakaya H, Taguchi M, Oguchi A, Ichikawa N, Nishiko R, Yamazaki S, Fujita N, Watanabe H, et al. Antimicrob Agents Chemother. 2011 Feb; 55(2):623-30. Epub 2010 Nov 22.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Life-threatening bacteraemia in HIV-1 seropositive adults admitted to hospital i...
Life-threatening bacteraemia in HIV-1 seropositive adults admitted to hospital in Nairobi, Kenya.
Lancet. 1990 Sep 1 ;336(8714):545-9.

PubMed
Distinct domains of the protein tyrosine kinase tyk2 required for binding of int...
Distinct domains of the protein tyrosine kinase tyk2 required for binding of interferon-alpha/beta and for signal transduction.
J Biol Chem. 1995 Feb 17 ;270(7):3327-34.

PubMed
Video-assisted thoracoscopy in the management of recurrent spontaneous pneumotho...
Video-assisted thoracoscopy in the management of recurrent spontaneous pneumothorax.
Eur J Surg. 1995 Apr ;161(4):227-30.

PubMed
MHCPEP, a database of MHC-binding peptides: update 1997.
MHCPEP, a database of MHC-binding peptides: update 1997.
Nucleic Acids Res. 1998 Jan 1 ;26(1):368-71.

PubMed
Roman arches, human joints, and disease: differences between convex and concave ...
Roman arches, human joints, and disease: differences between convex and concave sides of joints.
Arthritis Rheum. 1980 Nov ;23(11):1308-11.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: