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J Bacteriol. 2009 Nov;191(22):7134-9. doi: 10.1128/JB.01000-09. Epub 2009 Sep 11.

YjhS (NanS) is required for Escherichia coli to grow on 9-O-acetylated N-acetylneuraminic acid.

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  • 1Laboratory of Sialobiology, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA.

Abstract

The nanATEK-yhcH, yjhATS, and yjhBC operons in Escherichia coli are coregulated by environmental N-acetylneuraminic acid, the most prevalent sialic acid in nature. Here we show that YjhS (NanS) is a probable 9-O-acetyl N-acetylneuraminic acid esterase required for E. coli to grow on this alternative sialic acid, which is commonly found in mammalian host mucosal sites.

PMID:
19749043
[PubMed - indexed for MEDLINE]
PMCID:
PMC2772488
Free PMC Article
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