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J Allergy Clin Immunol. 2009 Nov;124(5):949-53. doi: 10.1016/j.jaci.2009.07.024. Epub 2009 Sep 12.

Fractional exhaled nitric oxide measurements are most closely associated with allergic sensitization in school-age children.

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  • 1Department of Pediatrics, University of Wisconsin-Madison, Madison, Wis, USA. djj@medicine.wisc.edu

Abstract

BACKGROUND:

Factors affecting fractional exhaled nitric oxide (FeNO) in early childhood are incompletely understood.

OBJECTIVE:

To examine the relationships between FeNO and allergic sensitization, total IgE, atopic dermatitis, rhinitis, asthma, and lung function (spirometry) in children.

METHODS:

Children at high risk of asthma and other allergic diseases because of parental history were enrolled at birth and followed prospectively. FeNO was measured by an online technique at ages 6 and 8 years. Relationships among FeNO, various atopic characteristics, and asthma were evaluated.

RESULTS:

Reproducible FeNO measurements were obtained in 64% (135/210) of 6-year-old and 93% (180/194) of 8-year-old children. There was seasonal variability in FeNO. Children with aeroallergen sensitization at ages 6 and 8 years had increased levels of FeNO compared with those not sensitized (geometric mean; 6 years, 10.9 vs 6.7 parts per billion [ppb], P < .0001; 8 years, 14.6 vs 7.1 ppb, P < .0001). FeNO was higher in children with asthma than in those without asthma at 8 years but not 6 years of age (6 years, 9.2 vs 8.3 ppb, P = .48; 8 years, 11.5 vs 9.2 ppb, P = .03). At 8 years of age, this difference was no longer significant in a multivariate model that included aeroallergen sensitization (P = .33). There were no correlations between FeNO and spirometric indices at 6 or 8 years of age.

CONCLUSION:

These findings underscore the importance of evaluating allergen sensitization status when FeNO is used as a potential biomarker in the diagnosis and/or monitoring of atopic diseases, particularly asthma.

PMID:
19748661
[PubMed - indexed for MEDLINE]
PMCID:
PMC2784153
Free PMC Article
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