Bupropion is an antidepressant, which has recently been promoted for the treatment of bipolar depression, because of its lower potency to induced switch. However, due to its dopamine enhancing effect, it has been reported to induce psychosis and perceptual changes. Most of the literature, which is available in relation to development of psychosis while receiving bupropion, has been with the use of immediate release formulation. Some of the case report which have reported development of psychosis with sustained release Bupropion, it has been reported in the background history of over dosage or substance abuse. We present case in which use of bupropion led to development of frank psychosis, which responded to use of antipsychotic medication. However, when antipsychotics were stopped, psychosis again recurred and as a result diagnosis of patient was changed.