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Nature. 2009 Sep 10;461(7261):218-23. doi: 10.1038/nature08454.

Molecular networks as sensors and drivers of common human diseases.

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  • 1Pacific Biosciences, 1505 Adams Drive, Menlo Park, California 94025, USA.


The molecular biology revolution led to an intense focus on the study of interactions between DNA, RNA and protein biosynthesis in order to develop a more comprehensive understanding of the cell. One consequence of this focus was a reduced attention to whole-system physiology, making it difficult to link molecular biology to clinical medicine. Equipped with the tools emerging from the genomics revolution, we are now in a position to link molecular states to physiological ones through the reverse engineering of molecular networks that sense DNA and environmental perturbations and, as a result, drive variations in physiological states associated with disease.

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