Mucosal Immunol. 2009 Nov;2(6):468-71. Epub 2009 Sep 9.

Diverse regulatory pathways for IgA synthesis in the gut.

Source

Laboratory for Mucosal Immunity, Research Center for Allergy and Immunology, Tsurumi, Yokohama, Japan.

Abstract

Immunoglobulin (Ig) A is the most abundant antibody isotype in mucosal secretions. In this study we summarize recent advances in our understanding of the compartments and mechanisms of intestinal IgA synthesis. We discuss the pathways leading to the generation of IgA(+) B cells in follicular and extra-follicular structures, by T-cell-dependent and T-cell-independent mechanisms.

PMID:: 19741602; [PubMed - indexed for MEDLINE]

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Review

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Immunoglobulin A

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