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    J Infect Dev Ctries. 2008 Aug 30;2(4):324-7.

    A case report and review of the literature: ciprofloxacin resistant Salmonella enterica serovar Typhi in India.

    Harish BN, Menezes GA, Sarangapani K, Parija SC.

    Source

    Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry-605006, India. drbnharish@yahoo.com

    Abstract

    BACKGROUND:

    Enteric fever is a major public health problem in India. The current treatment of choice is the fluoroquinolones.

    METHODS:

    The minimum inhibitory concentration (MIC) of ciprofloxacin was determined by E-test, HIMEDIA HiComb MIC test and agar dilution.

    RESULTS:

    An isolate of Salmonella enterica serovar Typhi (S. Typhi) from a case of enteric fever gave a ciprofloxacin MIC of 64 microg/ml.

    CONCLUSIONS:

    To our knowledge there have been no reports of such high-level resistance to ciprofloxacin in S. Typhi from southern India. HIMEDIA HiComb MIC test method is an alternative to the E-test. Ciprofloxacin resistant typhoid fever responds to treatment with ceftriaxone.

    PMID:
    19741296
    [PubMed - indexed for MEDLINE]
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