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Cancer Lett. 2010 Mar 1;289(1):71-80. doi: 10.1016/j.canlet.2009.08.004. Epub 2009 Sep 8.

Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer.

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  • 1Wellcome Trust Centre for Stem Cell Research, Tennis Court Road, Cambridge CB2 1QR, UK.

Abstract

We have examined expression of the Myc target gene Misu (NSUN2) in breast cancer. There was extensive copy number gain, and increased mRNA and protein levels, of Misu in approximately one third of breast cancer cell lines and primary tumours examined, irrespective of tumour subtype. Genes on 5p15.31-33, where Misu is located, showed evolutionary synteny. siRNA-mediated knockdown of Misu reduced cell number in over half of the cell lines tested, irrespective of estrogen receptor status. We conclude that Misu is up-regulated in a substantial proportion of breast cancers and has therapeutic potential as a drug target.

Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

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