Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA. rajkumar.vincent@mayo.edu
Monoclonal gammopathy of undetermined significance (MGUS) is a common premalignant plasma cell proliferative disorder with a lifelong risk of progression to multiple myeloma. Because myeloma is an incurable malignancy, strategies to delay or prevent progression in high-risk patients are of considerable importance.