Scaling of BMP gradients in Xenopus embryos

Nature. 2009 Sep 3;461(7260):E1; discussion E2. doi: 10.1038/nature08305.

Abstract

Metazoan organisms can 'scale', that is, maintain similar proportions regardless of size. Ben-Zvi et al. use experiments in Xenopus to support a quantitative model that explains morphological scaling as the result of scaling of a gradient of bone morphogenetic protein (BMP) signals. We believe that the evidence for scaling in Xenopus is misinterpreted, and that their model for embryonic patterning disagrees with prior data. The experiments they present supporting their model admit alternative interpretations.

Publication types

  • Comment

MeSH terms

  • Animals
  • Body Patterning*
  • Body Size
  • Bone Morphogenetic Proteins / metabolism*
  • Diffusion
  • Glycoproteins / deficiency
  • Intercellular Signaling Peptides and Proteins / deficiency
  • Larva / anatomy & histology
  • Larva / growth & development
  • Models, Biological*
  • Xenopus laevis / anatomy & histology
  • Xenopus laevis / embryology*
  • Xenopus laevis / growth & development
  • Xenopus laevis / metabolism*

Substances

  • Bone Morphogenetic Proteins
  • Glycoproteins
  • Intercellular Signaling Peptides and Proteins
  • chordin