Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Biol. 2009 Sep 2;8(8):74. doi: 10.1186/jbiol173.

Complementary pathways in mammalian female sex determination.

Author information

  • 1Department of Genetic Medicine and Development, University of Geneva Medical School, 1211 Geneva 4, Switzerland. serge.nef@unige.ch

Abstract

In mammals, the sex of the embryo is determined by the fate of the gonad. Recent papers, including one in BMC Developmental Biology, shed light on the molecular regulation of ovarian development and suggest that the R-spondin1/Wnt4/beta-catenin pathway and the Foxl2 transcription factor act in a complementary manner to promote ovarian fate and to repress testicular development.

PMID:
19735582
[PubMed - indexed for MEDLINE]
PMCID:
PMC2776915
Free PMC Article

Images from this publication.See all images (1)Free text

Figure 1
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk