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    Biochemistry. 2009 Sep 15;48(36):8491-3.

    Arabidopsis thaliana mitochondrial glyoxalase 2-1 exhibits beta-lactamase activity.

    Limphong P, Nimako G, Thomas PW, Fast W, Makaroff CA, Crowder MW.

    Source

    Department of Chemistry and Biochemistry, 160 Hughes Hall, 701 East High Street, Miami University, Oxford, Ohio 45056, USA.

    Abstract

    In an effort to determine the physiological role of Arabidopsis thaliana Glx2-1, we attempted to uncover a substrate for the enzyme. Glx2-1 did not effectively process 192 diverse substrates found in a commercial screen used for microorganism identification or exhibit arylsulfatase, lactonase, or phosphotriesterase activities. However, Glx2-1 does exhibit beta-lactamase activity with k(cat)/KM values from 10(3) to 10(5) M(-1) s(-1). Glx2-1 can hydrolyze cephalosporins and carbapenems, albeit with rate constants slower than those of most metallo-beta-lactamases. The potential role of a beta-lactamase in the mitochondria of plant cells is briefly discussed.

    PMID:
    19735113
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2747047
    Free PMC Article

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