Trends Parasitol. 2009 Oct;25(10):441-3. Epub 2009 Sep 4.

Virulence and drug resistance in malaria parasites.

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Biological Chemistry, Silberman Institute of Life Sciences, Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel.

Abstract

Virulence and drug resistance are traits that pathogens can acquire independently, albeit these traits can influence each other. A recent publication has reported on the co-evolution of virulence and pyrimethamine resistance in malaria parasites. Here, we discuss this finding in the context of the folate biosynthesis pathway and explain how mutational changes in this pathway can affect both parasite replication rates and the development of drug resistance.

PMID:: 19734096; [PubMed - indexed for MEDLINE]

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Virulence and drug resistance in malaria parasites.

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