Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 2009 Sep 4;325(5945):1250-4. doi: 10.1126/science.1174921.

Rab35 controls actin bundling by recruiting fascin as an effector protein.

Author information

  • 1Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Actin filaments are key components of the eukaryotic cytoskeleton that provide mechanical structure and generate forces during cell shape changes, growth, and migration. Actin filaments are dynamically assembled into higher-order structures at specified locations to regulate diverse functions. The Rab family of small guanosine triphosphatases is evolutionarily conserved and mediates intracellular vesicle trafficking. We found that Rab35 regulates the assembly of actin filaments during bristle development in Drosophila and filopodia formation in cultured cells. These effects were mediated by the actin-bundling protein fascin, which directly associated with active Rab35. Targeting Rab35 to the outer mitochondrial membrane triggered actin recruitment, demonstrating a role for an intracellular trafficking protein in localized actin assembly.

PMID:
19729655
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk