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    Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1958-67. Epub 2009 Sep 3.

    Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin.

    Paterson AD, Lopes-Virella MF, Waggott D, Boright AP, Hosseini SM, Carter RE, Shen E, Mirea L, Bharaj B, Sun L, Bull SB; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group.

    Source

    Hospital for Sick Children, Toronto, Ontario, Canada. andrew.paterson@utoronto.ca

    Abstract

    BACKGROUND:

    Elevated serum soluble E-selectin levels have been associated with a number of diseases. Although E-selectin levels are heritable, little is known about the specific genetic factors involved. E-selectin levels have been associated with the ABO blood group phenotype.

    METHODS AND RESULTS:

    We performed a high-resolution genome-wide association study of serum soluble E-selectin levels in 685 white individuals with type 1 diabetes from the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Intervention and Complications (EDIC) study to identify major loci influencing levels. Highly significant evidence for association (P=10(-29)) was observed for rs579459 near the ABO blood group gene, accounting for 19% of the variance in E-selectin levels. Levels of E-selectin were higher in O/O than O/A heterozygotes, which were likewise higher than A/A genotypes. Analysis of subgroups of A alleles reveals heterogeneity in the association, and even after this was accounted for, an intron 1 SNP remained significantly associated. We replicate the ABO association in nondiabetic individuals.

    CONCLUSIONS:

    ABO is a major locus for serum soluble E-selectin levels. We excluded population stratification, fine-mapped the association to sub-A alleles, and also document association with additional variation in the ABO region.

    PMID:
    19729612
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3147250
    Free PMC Article

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