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    J Neurol Sci. 2009 Dec 15;287(1-2):105-7. Epub 2009 Sep 2.

    Association of anti-aquaporin-4 antibody-positive neuromyelitis optica with myasthenia gravis.

    Source

    Department of Neurology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. a-uzimp1204@graduate.chiba-u.jp

    Abstract

    We describe 2 patients who developed anti-aquaporin-4 antibody-positive neuromyelitis optica (NMO) following the development of anti-acetylcholine receptor antibody-positive myasthenia gravis (MG). A literature review of 13 similar cases in addition to the present 2 cases of NMO with MG showed predominance among Asian women and frequent development of NMO following thymectomy for MG. Moreover, in one of our patients, serial assays of anti-aquaporin-4 antibody and anti-acetylcholine receptor antibody were performed. Accumulating evidence for the coexistence of NMO and MG suggests that a common immunopathogenesis of NMO and MG may exist, and the association of NMO with MG may be more frequent than hitherto believed.

    PMID:
    19729173
    [PubMed - indexed for MEDLINE]

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