Hum Genet. 1990 Jun;85(1):125-6.

Regional localization by in situ hybridization of a human chromosome 9 marker tightly linked to the Friedreich's ataxia locus.

Raimondi E, Antonelli A, Driesel AJ, Pandolfo M.

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Dipartimento di Genetica e Microbiologia, A. Buzzati Traverso, dell'Università di Pavia, Italy.

Abstract

In order to determine the regional localization of the Friedreich's ataxia (FA) gene on chromosome 9, the DNA probe DR47 (D9S5), which detects a restriction fragment length polymorphism (RFLP) in tight linkage with the disease, was hybridized in situ to metaphase chromosomes. Our results enable the D9S5 locus to be assigned to the 9q12-q13 region, thus indicating that this is also the localization of the FA gene.

PMID:: 1972693; [PubMed - indexed for MEDLINE]

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Localization of DNA probes tightly linked to the Friedreich's ataxia locus by in situ hybridization in a case of pericentric inversion of chromosome 9. [Hum Genet. 1991]
Localization of DNA probes tightly linked to the Friedreich's ataxia locus by in situ hybridization in a case of pericentric inversion of chromosome 9.
Raimondi E, Bernasconi P, Moralli D, Fujita R, Uziel G, Di Donato S, De Carli L, Pandolfo M. Hum Genet. 1991 Mar; 86(5):525-8.
The Friedreich ataxia gene is assigned to chromosome 9q13-q21 by mapping of tightly linked markers and shows linkage disequilibrium with D9S15. [Am J Hum Genet. 1990]
The Friedreich ataxia gene is assigned to chromosome 9q13-q21 by mapping of tightly linked markers and shows linkage disequilibrium with D9S15.
Hanauer A, Chery M, Fujita R, Driesel AJ, Gilgenkrantz S, Mandel JL. Am J Hum Genet. 1990 Jan; 46(1):133-7.
Additional polymorphisms at marker loci D9S5 and D9S15 generate extended haplotypes in linkage disequilibrium with Friedreich ataxia. [Proc Natl Acad Sci U S A. 1990]
Additional polymorphisms at marker loci D9S5 and D9S15 generate extended haplotypes in linkage disequilibrium with Friedreich ataxia.
Fujita R, Hanauer A, Sirugo G, Heilig R, Mandel JL. Proc Natl Acad Sci U S A. 1990 Mar; 87(5):1796-800.
Review Attempts to identify the chromosomal localization of the Friedreich's ataxia locus. [Adv Neurol. 1988]
Review Attempts to identify the chromosomal localization of the Friedreich's ataxia locus.
Chamberlain S, Worrall C, Williamson R. Adv Neurol. 1988; 48:257-60.
Review Construction of a genetic linkage map in man using restriction fragment length polymorphisms. [Am J Hum Genet. 1980]
Review Construction of a genetic linkage map in man using restriction fragment length polymorphisms.
Botstein D, White RL, Skolnick M, Davis RW. Am J Hum Genet. 1980 May; 32(3):314-31.

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Regional localization by in situ hybridization of a human chromosome 9 marker tightly linked to the Friedreich's ataxia locus.

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